Cortactin蛋白在结直肠癌中的表达变化及其临床意义?

doi:10.3969/j.issn.1004-616x.2014.01.005

Abstract

Abstract:

OBJECTIVE: To investigate the alteration of cortactin (CTTN) expression in colorectal cancer (CRC) and its correlation with clinico-pathological characteristics and prognosis. METHODS：Immunohistochemistry method was used to detect the expression of CTTN in 100 cases of CRC and adjacent normal tissues. The relationship between CTTN expression and clinico-pathological features and prognosis of the patients was evaluated. RESULTS： Positive rate of CTTN expression in colorectal cancer tissues was significantly higher than that in adjacent normal tissues (P＜0.01). Expression of CTTN was correlated with depth of tumor invasion (P＝0.037). A Kaplan-Meier survival analysis revealed that the patients with CTTN expression had a shorter overall survival (OS) than those with negative CTTN (P = 0.014). CONCLUSION：CTTN overexpression was a common event，and seemed to be a poor prognostic factor for colorectal cancer.

Key words: Cortactin, colorectal cancer, immunohistochemistry, prognosis

ZHANG Tong-tong,LIANG Jian-wei，WANG Zheng，ZHANG Yu，LIU Yi-zhen，SHANG Li，YANG Hai，CAI Yan，XU Xin，WANG Ming-rong.

Altered expression and prognostic significance of cortactin in colorectal cancer

[J]. Carcinogenesis, Teratogenesis & Mutagenesis, doi: 10.3969/j.issn.1004-616x.2014.01.005.

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Altered expression and prognostic significance of cortactin in colorectal cancer

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