体外硫芥对人外周血淋巴细胞DNA 的损伤

doi:10.3969/j.issn.1004-616x.2001.01.006

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2001, Vol. 13 ›› Issue (1): 17-019.doi: 10.3969/j.issn.1004-616x.2001.01.006

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THE DNA DAMAGE OF HUMAN PERIPHERAL BLOOD LYMPHOCYTES EXPOSURE TO SULFURMUSTARD IN VITRO

YU Wei, SUN Jin-su, YAN Chang-hui, ZHANG Hui-li

Beijing Medical College of PLA, Beijing 100071, China

Received:1999-07-20 Revised:2000-12-27 Online:2001-01-30 Published:2001-01-30

Abstract

Abstract: Purpose and Methods : Using the alkaline single cell gel elect rophoresis technique (SCGE) detect the DNA damage of lymphocytes in human peripheral blood , which were exposed to Sulfur mustard in vit ro. Results and Conclusion : The result s show that the length of DNA migration and the f requency of tailed cells increase , and the dose - effect relation is obvious.

Key words: sulfur mustard, alkaline single cell gel elect rophoresis assay, lymphocytes, DNA damage

CLC Number:

R827117 + 4

YU Wei, SUN Jin-su, YAN Chang-hui, ZHANG Hui-li. THE DNA DAMAGE OF HUMAN PERIPHERAL BLOOD LYMPHOCYTES EXPOSURE TO SULFURMUSTARD IN VITRO[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2001, 13(1): 17-019.

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THE DNA DAMAGE OF HUMAN PERIPHERAL BLOOD LYMPHOCYTES EXPOSURE TO SULFURMUSTARD IN VITRO

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