低氧诱导因子-1α 与卵巢上皮癌临床病理关系的Meta分析

doi:10.3969/j.issn.1004-616x.2014.01.011

Abstract

Abstract:

OBJECTIVE: To explore the expression of hypoxia inducible factor-1α (HIF-1α) in epithelial ovarian cancer and its relationship with clinical pathology，in order to understand the effect of HIF-1α in malignant biological behavior of ovarian epithelial carcinoma clear. METHODS：Original foreign literatures on the correlation between HIF-1α and epithelial ovarian cancer were selected from Cochrane Library，EMbase database，Pubmed，and Chinese original literatures were from CNKI，CBM. All analyses were performed by software STATA 11.0. Relationships between HIF-1α expression and age，pathological type，histological grade，lymph node metastasis，clinical stage were analyzed using pooled odds ratio (OR) with 95% confidence interval (CI). RESULTS：A total of 6 papers including 257 cases of epithelial ovarian cancer were analyzed. Compared with that in normal tissue，total positive rate of HIF-1αin epithelial ovarian cancer was 72.4%，which was increased significantly (OR=0.036，95%CI：0.010-0.135，P=0.000)； HIF-1α was significantly correlated with lymph node metastasis and clinical stage(OR=0.080，95%CI：0.029-0.220，P=0.000； OR=0.258， 95%CI：0.136-0.490， P=0.000). Patients with positive expression of HIF-1α were prone to lymph node metastasis and advanced clinical stage. HIF-1α had no significant relation with age，pathological type and pathological grading (P>0.05). CONCLUSION：The expression of HIF-1α protein increased the risk of epithelial ovarian cancer. HIF-1α could be used as indicator of lymph node metastasis and clinical stage.

Key words: hypoxia inducible factor-1α, ovarian carcinoma, hypoxia, immunohistochemistry

SUN Caixia，JING Shaowu，WANG Jun，XU Yingjie. Relationship between hypoxia inducible factor -1α and clinicopathology of epithelial ovarian cancer：Meta analysis[J]. Carcinogenesis, Teratogenesis & Mutagenesis, doi: 10.3969/j.issn.1004-616x.2014.01.011.

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Relationship between hypoxia inducible factor -1α and clinicopathology of epithelial ovarian cancer：Meta analysis

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