川贝枇杷糖急性毒性和致突变性实验研究

doi:10.3969/j.issn.1004-616x.2003.04.017

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2003, Vol. 15 ›› Issue (4): 240-241.doi: 10.3969/j.issn.1004-616x.2003.04.017

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STUDIES ON ACUTE TOXICITY AND MUTAGENICITY OF CHUANBEIPIBA POLYSACCHARIDES

GAO Ju-mei, LIU Min, QING Guang-he, et al

Yunnan Center fo r Disease Control and Prevention, Kunming 650022,China

Received:2003-02-10 Revised:2003-05-14 Online:2003-10-30 Published:2003-10-30
Contact: GAO Ju-mei

Abstract

Abstract: Purpose: To study the acute toxicity and the mutagenicity of Chuanbeipiba polysaccharides. Methods: The oral acute toxicity tests in rats and mice, Ames test, micronucleus test of polychromatic erythrocytes in bone marrow and sperm shape abnormality test were carried out. Results: LD50 in rats and mice were more than 10 g/kg; The micronucleus rates and sperm abnormality rates in all doses were not significantly different from the control group(P>0.05), respectively. But those rates in positive group were higher than in the negative control group(P<0.01).No increase in the number of revertant colonies was found in the Ames test with and without S 9 mix Conclusion: Acute toxicity and the mutagenicity of Chuanbeipiba polysaccharides were not observed in this study.

Key words: chuanbeipiba polysaccharides, acute toxicity, mutagenicity

GAO Ju-mei, LIU Min, QING Guang-he, et al. STUDIES ON ACUTE TOXICITY AND MUTAGENICITY OF CHUANBEIPIBA POLYSACCHARIDES[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2003, 15(4): 240-241.

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STUDIES ON ACUTE TOXICITY AND MUTAGENICITY OF CHUANBEIPIBA POLYSACCHARIDES

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