Carcinogenesis, Teratogenesis & Mutagenesis ›› 2000, Vol. 12 ›› Issue (4): 211-213.doi: 10.3969/j.issn.1004-616x.2000.04.005

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ANT10XIDATIVE ABILITY 0F CARB0XYETHYLGERMANIUM (GE一1 32) 0N THE AFB1 INDUCED HEPAT0CARCIN0GENESIS IN RAT

HOU Hua—xin，LI Dan—mng，TU Wen—sheng．et ai   

  1. Guangxi Medical University，Nanning 530021．China
  • Received:1999-04-09 Revised:1999-11-02 Online:2000-10-30 Published:2000-10-30

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Abstract: Results：This paper reports that Ge一132 possessed the remarkable resistance effeets on AFB．reducing Superoxide Dismutase(SOD)activity in vivo during AFBt—induced hepatocarcinogenesis for short term modal experiments The SOD activity can be affected by the time and the dosage of Ge一132 intaken．Conclusion：The results indicated that antioxidative ability of Ge一132 is relate to im anticareiogenicity．Ge一132 can be used ∞ a safe and efective chemopreventlon agent．

Key words: aflatoxin Bt(AFB1), earboxyethylgermanium (Ge一132), supemxide dismutase(SOD)

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