Carcinogenesis, Teratogenesis & Mutagenesis ›› 2010, Vol. 22 ›› Issue (3): 214-217.doi: 10.3969/j.issn.1004-616x.2010.03.013

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Expression and significance of ESR1 in thyroid tumor tissues in Xinjiang

YANG Xi1;Ayshamgul.Hasim2;SHAO Feng2;WU Shuang1;Abulizi.Abudula3;Xiamixinuer.Yilike1   

  1. (1. Biology Department, Pre-clinical College of Xinjiang Medical University, Urumqi 830011; 2. Pathology Department, Pre-clinical College of Xinjiang Medical University, Urumqi 830011;3. Molecular Biology Laboratory, Pre-clinical College of Xinjiang Medical University, Urumqi 830011, Xinjiang, China
  • Received:2009-11-12 Revised:2010-03-19 Online:2010-05-30 Published:2010-05-30
  • Contact: Xiamixinuer.Yilike

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Abstract: OBJECTIVE: To investigate the expression of estrogen receptor alpha(ESR1) in thyroid cancer tissues and explore its clinical value. METHODS: The paraffin-embedded tissue sections of 64 thyroid cancer patients, 21 cases of thyroid adenoma, 13 cases of Hashimoto's thyroiditis, 6 cases of nodular goiter and 6 cases from the peri-tumor tissue were immunohistochemically examined for the expression of ESR1. The association between ESR1 expression and clinico- pathological parameters were analyzed. RESULTS: The positive rate of ESR1 in thyroid cancer tissues was significantly higher than those in thyroid adenoma, Hashimoto's thyroiditis, nodular goiter and peritumor tissues(P<0.01). The positive expression of ESR1 correlated significantly with tissue stage, clinical stage , lymph node metastasis and prognosis(P<0.05). CONCLUSION: ESR1 could play an important role in the occurrence and development of differentiated thyroid cancer, so to prevent the function of ESR1 may provide a new strategey to cure the thyroid cancer.

Key words: thyroid carcinoma, ESR1, immunohistology

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