镍化合物诱发恶性转化细胞的端粒酶活性表达

doi:10.3969/j.issn.1004-616x.2003.04.001

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2003, Vol. 15 ›› Issue (4): 193-194.doi: 10.3969/j.issn.1004-616x.2003.04.001

TELOMERASE ACTIVITY IN THE MALIGNANT PROCESS OF CELLS INDUCED BY NICKEL COMPOUNDS

WANG Min, WU Zhong-liang, CHEN Jia-kun

Institute for Chemical Carcinogenesis, Guangzhou Medical College, GuangZhou 510182, China

Received:2003-02-24 Revised:2003-03-31 Online:2003-10-30 Published:2003-10-30
Contact: CHEN Jia-kun

Abstract

Abstract: Purpose: To explore the telomerase activity in the malignant process of BALB/c-3T3 cells induced by crystalline nickel sulfide, nickel chloride. Methods: TRAP-sliver staining assay was used to detect the telomerase activity. Results: Telomerase activity in BALB/c-3T3 cells transformed by nickel sulfide and nickel chloride were all positive. Conclusion: The positive expression of telomerase activity in the cell transformation might be related to the nickel carcinogenesis.

Key words: nickel compounds, transformed cells, tumor cells, telomerase activity

WANG Min, WU Zhong-liang, CHEN Jia-kun. TELOMERASE ACTIVITY IN THE MALIGNANT PROCESS OF CELLS INDUCED BY NICKEL COMPOUNDS[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2003, 15(4): 193-194.

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TELOMERASE ACTIVITY IN THE MALIGNANT PROCESS OF CELLS INDUCED BY NICKEL COMPOUNDS

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