香加皮水提物对小鼠淋巴细胞免疫调节作用的初步研究

doi:10.3969/j.issn.1004-616x.2010.04.010

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2010, Vol. 22 ›› Issue (4): 292-294.doi: 10.3969/j.issn.1004-616x.2010.04.010

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The immunoregulatory activity of cortex periplocae extract on the mice lymphocyts

LI Jun-xin1;JIANG Yu-hong1;SHAN Bao-en2

1. Women and Children's Medical Center, Qingdao 266011，Shandong；2. Science and Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei, China

Received:2010-03-12 Revised:2010-04-21 Online:2010-07-30 Published:2010-07-30
Contact: LI Jun-xin

Abstract

Abstract: OBJECTIVE: Study on the immunoregulatory function of cortex periplocae extract(CPE) on mice lymphocytes. METHODS: We separated mice lymphocytes with aseptic manipulation and cultivated them with CPE(concentrations were 250,125,64,32,16,8 μg/ml), Then the effect of CPE on the proliferative activity of mice lymphocytes induced by ConA was measured by using MTT method. The activity of NK cells was assayed by a released LDH assay. The content of tumor necrosis factor-α(TNF-α) was evaluated by biological method. RESULTS: CPE within the range of 8 to 64 μg/ml could markedly stimulate the mice lymphocyte to proliferate and enhance the activity of NK cells. It stimulated monocytes to produce TNF-α as well. CONCLUSION: CPE showed immunoregulatory activity on mice lymphocytes. This could be used clinically for modulating immune response or for treating tumors and other diseases.

Key words: cortex periplocae extract, mice, lymphocytes, immunoregulatory activity

CLC Number:

R979.1

LI Jun-xin, JIANG Yu-hong, SHAN Bao-en. The immunoregulatory activity of cortex periplocae extract on the mice lymphocyts[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2010, 22(4): 292-294.

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The immunoregulatory activity of cortex periplocae extract on the mice lymphocyts

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