Carcinogenesis, Teratogenesis & Mutagenesis ›› 2003, Vol. 15 ›› Issue (4): 234-236.doi: 10.3969/j.issn.1004-616x.2003.04.015

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STUDY OF TER ATOGENICITY OF PIOGILISTAZONE HYDROCHLORIDA IN RATS

LIAO Xue1， WANG Jie1， SONG Hong-yu1， et al   

  1. 1.National Research Center for New Drug Safety Evaluation ,Shenyang 110021,China;2.The Ninth Hospital of Shenyang, shenyang 110024,China
  • Received:2003-03-10 Revised:2003-06-28 Online:2003-10-30 Published:2003-10-30
  • Contact: LIAO Xue

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Abstract: Purpose: This study was undertaken to determine the potentially teratogenic effects of pioglitazone hydrochloride to Wistar rats. Methods: The study was conducted with three groups orally administered with 6, 24, and 96 mg/kg doses continuously for 10 days from 6th to 15th day after gestation of rats. Positive (2 mg/kg Dikushuang) and negative controls (0.5 ％ CMCNa) were performed at the same time with the method. Results: the number of absorptive embryo and dead fetus increased in the high dose group (96 mg/kg). The stunt effect of pioglitazone hydrochloride to the fetus was observed in all dose groups. Conclusion: Pioglitazone hydrochloride showed obvious embryo toxicity, but no teratogenic effect to fetus was observed.

Key words: pioglitazone hydrochloride, Wistar rat, embryo toxicity, teratogenicity