Carcinogenesis, Teratogenesis & Mutagenesis ›› 2004, Vol. 16 ›› Issue (3): 178-180.doi: 10.3969/j.issn.1004-616x.2004.03.016

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Acute Toxicity and Mutagenicity Tests of Four Species Disinfectants

ZHAO Sheng-you，JIANG Xiao-chun，WANG Yan-qiu，et al   

  1. Jilin Center for Disease Control and Prevention,Changchun 130021,China
  • Received:2003-12-23 Revised:2004-02-16 Online:2004-05-30 Published:2004-05-30
  • Contact: ZHAO Sheng-you

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Abstract: BACKGROUND ＆ AIM:To test the acute toxicity and the mutagenicity of Qianglilu disinfectants,Juweitongdian solution,High consistence Ozonic water generator and neuter consolidated Glutaraldehyde. MATERIAL AND METHODS:The oral actute toxicity tests and micronucleus test of polychromatic erythrocytes in bone marrow of rats. RESULTS: LD50 of Qianglilu disinfectants were 3 690 mg/kg in female rats and 2 710 mg/kg in male rats. LD50 of Juweitongdian solution and High consistence Ozonic water in rats were more than 10 000 mg/kg. LD50 of neuter consolidated Glutaraldehyde in rats were more than 5 000 mg/kg.The micronucleus rats in all doses and in different sex were not significantly different from the control group(P>0.05),respectively. CONCLUSION: Qianglilu disinfectants is low toxic materials. Juweitongdian solution,High consistence Ozonic water and neuter consolidated Glutaraldehyde are not toxic materials in fact.The mutagenicity of four species disinfectants were not observed in the study.

Key words: disinfectants, actute toxicity, mutagenicity