邻苯二甲酸酯类化合物的生殖毒性及其环境内分泌干扰效应

doi:10.3969/j.issn.1004-616x.2015.04.013

摘要/Abstract

摘要： 邻苯二甲酸酯类(PAEs)增塑剂是广泛存在于人类生活环境中的化合物之一。由于其环境内分泌干扰效应受到全球相关领域的高度关注。它经过食物链进入人体并蓄积在体内,影响人类生殖健康,对生殖、发育、激素分泌以及基因表达造成损害。目前的研究表明,PAEs可引起生殖能力受损,并对后代发育产生影响。且PAEs通过内分泌干扰效应,干扰体内相关激素的分泌与功能,其在血液和尿液中的代谢物与糖尿病的发生密切相关。因此,本文主要对PAEs的生殖毒性及其环境内分泌干扰效应的研究进展作一综述。

关键词: 增塑剂, 生殖毒性, 内分泌干扰效应, 邻苯二甲酸酯

中图分类号:

R994.6

吴德生, 秦逍云, 谭琴, 徐新云. 邻苯二甲酸酯类化合物的生殖毒性及其环境内分泌干扰效应[J]. 癌变·畸变·突变, 2015, 27(4): 316-318,322.

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