4-硝基喹啉-1-氧化物诱导食管鳞状细胞癌发生的研究进展

doi:10.3969/j.issn.1004-616x.2016.02.015

癌变·畸变·突变 ›› 2016, Vol. 28 ›› Issue (2): 151-154.doi: 10.3969/j.issn.1004-616x.2016.02.015

4-硝基喹啉-1-氧化物诱导食管鳞状细胞癌发生的研究进展

陈欣然¹, 王玲², 王薇^1,3, 韩利霞^1,4, 刘莉^1,5, 单保恩^1,2

1. 河北医科大学第四医院科研中心, 河北石家庄 050035;
2. 河北医科大学第四医院肿瘤研究所免疫室, 河北石家庄 050035;
3. 河北省人民医院临床检验科, 河北石家庄 050057;
4. 河北省儿童医院输血科, 河北石家庄 050030;
5. 白求恩国际和平医院256临床部检验科, 河北石家庄 050080

收稿日期:2015-07-01 修回日期:2015-12-03 出版日期:2016-03-31 发布日期:2016-03-31
通讯作者: 单保恩,E-mail:shanbaoen_1962@163.com E-mail:shanbaoen_1962@163.com
作者简介:陈欣然,E-mail:cxrtht@163.com
基金资助:
国家自然科学基金项目(81173611);河北省重点医学科研课题(zd2013045);河北省教育厅学位办高等学校研究生创新资助项目

Received:2015-07-01 Revised:2015-12-03 Online:2016-03-31 Published:2016-03-31

摘要/Abstract

摘要： 食管鳞状细胞癌(ESCC)是一种常见且预后较差的恶性肿瘤,其发病机制尚未完全明确。建立ESCC模型,研究ESCC发病机制,对于降低ESCC的发病率和病死率具有重要意义。4-硝基喹啉-1-氧化物(4NQO)是一种肿瘤诱导剂,已广泛用于口腔癌的研究,而在ESCC研究中的应用还较少。因此,本文就4NQO体内代谢特点、诱导ESCC模型及诱癌机制的相关文献进行综述,以期为食管癌的防治提供一些新的研究线索。

关键词: 4-硝基喹啉-1-氧化物, 食管鳞状细胞癌, 癌前病变, 肿瘤诱导剂

中图分类号:

R735.1

陈欣然, 王玲, 王薇, 韩利霞, 刘莉, 单保恩. 4-硝基喹啉-1-氧化物诱导食管鳞状细胞癌发生的研究进展[J]. 癌变·畸变·突变, 2016, 28(2): 151-154.

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4-硝基喹啉-1-氧化物诱导食管鳞状细胞癌发生的研究进展

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