常用辐射生物剂量计的研究现状

doi:10.3969/j.issn.1004-616x.2016.04.017

摘要/Abstract

摘要： 随着放射源及射线装置的广泛应用，涉核人员的数量有了大幅度提升。生物剂量计无论是在职业人员的健康监护方面还是事故受照人员的剂量估算方面都有着不可替代的作用。本文从细胞水平和分子水平进行分类，对近年来研究较多的几种辐射生物剂量计进行综述并介绍了各自的优缺点。细胞水平有染色体畸变分析、微核分析、早熟凝集染色体分析等传统的生物剂量计。分子水平涉及到GPA、HPRT、γ-H2AX、线粒体DNA 4977 bp片段等有望用于辐射生物剂量估算的基因或基因片段。生物剂量计发展的必然趋势是快速、简单、高通量。快速生物剂量自动分析系统满足以上特点，代表了未来辐射生物剂量计的一个重要研究方向，因此本文也对其进行了简要介绍，以便为新型生物剂量计的研究提供参考。

关键词: 生物剂量计, 电离辐射, 染色体畸变, 自动分析

中图分类号:

TB98

张忠新, 张睿凤, 张慧芳, 段志凯. 常用辐射生物剂量计的研究现状[J]. 癌变·畸变·突变, 2016, 28(4): 325-328.

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