蛋白磷酸酶2A在线粒体质量控制中的作用研究进展

doi:10.3969/j.issn.1004-616x.2019.01.014

摘要/Abstract

摘要： 蛋白磷酸酶2A（PP2A）是真核细胞内广泛表达的丝/苏氨酸蛋白磷酸酶家族成员之一，通过去磷酸化作用参与外源物诱导细胞毒性损伤和致癌过程中关键调控蛋白的可逆磷酸化，进而抑制绝大多数丝/苏氨酸激酶的活性。近年来，PP2A在线粒体质量控制（MQC）中的作用逐渐被认识，广泛参与线粒体生物发生、线粒体动态、线粒体氧化还原平衡和线粒体自噬等重要生物学过程，对拓展MQC相关蛋白翻译后修饰在以线粒体为核心枢纽的信号流中的研究具有重要意义。本文重点阐述PP2A介导的去磷酸化机制在MQC调控中的作用，为从翻译后修饰层面阐明外源物诱导线粒体关联性损伤和致癌作用或肿瘤相关疾病的分子机制、以及为人群暴露和危害标志物的筛查和靶向干预提供依据。

关键词: 蛋白磷酸酶2A, 线粒体质量控制, 线粒体生物发生, 线粒体动态, 线粒体氧化还原, 线粒体自噬

中图分类号:

Q291

车琳, 林忠宁, 林育纯. 蛋白磷酸酶2A在线粒体质量控制中的作用研究进展[J]. 癌变·畸变·突变, 2019, 31(1): 73-78.

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