病毒致癌过程中的线粒体糖酵解代谢重编程机制研究进展

doi:10.3969/j.issn.1004-616x.2021.06.013

癌变·畸变·突变 ›› 2021, Vol. 33 ›› Issue (6): 470-474.doi: 10.3969/j.issn.1004-616x.2021.06.013

病毒致癌过程中的线粒体糖酵解代谢重编程机制研究进展

兰尤¹, 陈圆圆^1,2, 林忠宁¹, 林育纯¹

1. 厦门大学公共卫生学院分子疫苗学和分子诊断学国家重点实验室, 福建厦门 361102;
2. 中国疾病预防控制中心环境与健康相关产品安全所, 北京 100021

收稿日期:2021-01-30 修回日期:2021-09-11 出版日期:2021-11-30 发布日期:2021-12-04
通讯作者: 林育纯,E-mail:linych@xmu.edu.cn E-mail:linych@xmu.edu.cn
作者简介:兰尤,E-mail:1010584367@qq.com。
基金资助:
国家自然科学基金（81773465，81874272）

Received:2021-01-30 Revised:2021-09-11 Online:2021-11-30 Published:2021-12-04

摘要/Abstract

摘要： 病毒感染诱发癌症是公共卫生关注的问题之一。病毒基因编码的致癌蛋白，可诱发宿主细胞基因组的不稳定和原癌/抑癌基因的突变，促进宿主细胞恶性转化。代谢重编程指细胞在恶性转化过程中有一套异于正常细胞的代谢模式，涉及糖酵解、三羧酸循环和氧化磷酸化等过程，是致癌过程前（早）期阶段的标志之一。线粒体作为真核细胞重要的供能细胞器，在维持机体能量稳态过程中发挥重要作用，其中线粒体质量控制是线粒体稳态调节的重要方式之一。本文阐述I类致癌病毒表达的致癌蛋白诱导宿主细胞糖酵解代谢重编程相关的线粒体调节机制，以及靶向病毒感染和糖酵解代谢重编程的干预研究，为病毒致癌作用的预防和干预提供依据。

关键词: 病毒致癌蛋白, 糖酵解代谢重编程, 致癌过程, 线粒体质量控制, 靶向干预

中图分类号:

R730.2

兰尤, 陈圆圆, 林忠宁, 林育纯. 病毒致癌过程中的线粒体糖酵解代谢重编程机制研究进展[J]. 癌变·畸变·突变, 2021, 33(6): 470-474.

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病毒致癌过程中的线粒体糖酵解代谢重编程机制研究进展

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