环状RNA在肿瘤中作用的研究进展

doi:10.3969/j.issn.1004-616x.2020.06.013

癌变·畸变·突变 ›› 2020, Vol. 32 ›› Issue (6): 477-480,484.doi: 10.3969/j.issn.1004-616x.2020.06.013

环状RNA在肿瘤中作用的研究进展

张春雷^1,3, 杨琦^1,3, 訾晓渊^1,2, 孙颖浩¹

1. 海军军医大学长海医院泌尿外科, 上海 200433;
2. 海军军医大学细胞生物教研室, 上海 200433;
3. 联勤保障部队第九四○医院泌尿外科, 甘肃兰州 730050

收稿日期:2018-04-08 修回日期:2020-10-04 出版日期:2020-12-01 发布日期:2020-12-04
通讯作者: 訾晓渊,E-mail:zi_xiaoyuan@163.com;孙颖浩,E-mail:sunyhsmmu@126.com E-mail:zi_xiaoyuan@163.com;sunyhsmmu@126.com
作者简介:张春雷,E-mail:zhangchunlei7010@163.com。
基金资助:
上海市浦江人才计划资助项目（16PJ1411100）

Received:2018-04-08 Revised:2020-10-04 Online:2020-12-01 Published:2020-12-04

摘要/Abstract

摘要： 环状RNA（circRNAs）是一种通过反向剪接机制由线性RNA前体的5'端和3'端共价相接形成具有特殊环状结构的非编码RNA（ncRNAs），与基因的转录及转录后表达调控有关，可能以不同于其亲代转录本的新方式呈现遗传信息。近年，随着分子生物学、生物信息学以及高通量检测技术的不断发展，circRNAs逐渐被发现不仅存在于细菌、真菌、植物中，也大量存在于哺乳动物中。从作用于miRNAs和RNA结合蛋白，到充当转录调节因子，它们在基因调控和正常细胞稳态中的重要作用开始被认识。作为ncRNAs的新成员，circRNAs在多种疾病和肿瘤中的重要作用逐渐被发现。在此综述中，我们介绍了circRNAs的形成机制和功能，并总结了circRNAs在肿瘤发生和发展中的生物学作用。

关键词: 环状RNA, 微小RNA, 肿瘤发生, 生物学特性

中图分类号:

R730.231+.3

张春雷, 杨琦, 訾晓渊, 孙颖浩. 环状RNA在肿瘤中作用的研究进展[J]. 癌变·畸变·突变, 2020, 32(6): 477-480,484.

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环状RNA在肿瘤中作用的研究进展

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