Abstract: OBJECTIVE： To investigate the expression of Brahma-related gene 1-associated factor 57 (BAF57) in colorectal cancer (CRC) tissues and its impact on prognosis of patients. METHODS： The cancer and adjacent tissues of 110 CRC patients admitted to our hospital from January 2016 to January 2018 were selected as the study subjects. BAF57 expression was detected by Western blot and qPCR，respectively. Relationships between BAF57 expression levels and pathological parameters in the tissues were analyzed. Receiver operating characteristic curve and subject operator (ROC) curve were used to determine the relationships between BAF57 expression and diagnosis value. Survival time was analyzed by Kaplan-Meier and Log-rank. RESULTS： The BAF57 mRNA and protein levels were significantly higher in the CRC than those in the adjacent tissues (P<0.05). Both levels were positively correlated with TNM stages (r=0.913，P<0.01；r=0.925，P<0.01)， negatively related with tissue differentiation (r=-0.781，P<0.01；r=-0.888，P<0.01)；and positively with lymph node metastasis (r=0.744，P<0.01；r=0.743，P<0.01). ROC analysis showed that the area under the curve for BAF57 mRNA and protein for CRC diagnosis was 0.976 and 0.915，respectively. Survival analysis indicated that the median survival time of the BAF57 mRNA high-expression group (48.5 month) was significantly lower than the low-expression group (60.5 month，Log-rank χ²=4.985，P<0.05)，which was also found between the protein high- and low-expression groups (46.5 and 60.0 months，respectively；Log-rank χ²=4.469，P<0.05). CONCLUSION： BAF57 was highly expressed in CRC tissues and was positively associated with malignant progression and poor prognosis in patients.

Key words: colorectal cancer, BAF57, clinicopathology, prognosis