关键词: 光气, 红景天：丹参, 荷花粉, 氧化损伤

Abstract: OBJECTIVE: To study treatment effects of Integripetal rhodiola herb，Salvia miltiorrhiza and lotus flower pollen on injuries induced by phosgene in mice. METHODS：50 mice were randomly divided into 5 groups including Integripetal rhodiola herb group，Salvia miltiorrhiza group，lotus flower pollen group，positive control group and negative control group. The mice in negative control group were exposed to room air and the mice in other groups were exposed to 11.9 mg/L phosgene for 1 minute. After 20 minutes，mice in treatment groups were treated with integripetal rhodiola herb，Salvia miltiorrhiza and lotus flower pollen by 0.1ml/10g intragastric administration. Mice were sacrificed after 4 hour. The protein content in bronchoalveolar lavage fluid (BLAF)，the content of malondialdehyde (MDA) and reduced glutathione (GSH) and blood cell count were determined. RESULTS：The protein content of BLAF in integripetal rhodiola herb group decreased significantly compared with that of positive control (P<0.05). Peripheral blood platelet count increased significantly in mice treated with integripetal rhodiola herb and Salvia miltiorrhiza compared with positive control without treatment (P<0.05). MDA content decreased in three treatment groups and was significantly decreased in Integripetal rhodiola herb compared with positive control group (P<0.05). GSH content increased in three treatment groups and was increased significantly in Integripetal rhodiola herb group compared with positive control (P<0.05). CONCLUSION：Integripetal rhodiola herb， Salvia miltiorrhiza and lotus flower pollen exerted a therapeutic role on lung damage induced by phosgene in mice. Integripetal rhodiola herb efficacy was better than that of Salvia miltiorrhiza and lotus flower pollen.

Key words: phosgene, Integripetal rhodiola herb, Salvia miltiorrhiza, lotus flower pollen, oxidative injury