›› 2011, Vol. 23 ›› Issue (4): 306-307.doi: 10.3969/j.issn.1004-616x.2011.04.015

• 检测研究 • 上一篇    下一篇

海娜粉染发剂的致突变性研究

田 薇, 黄云飞, 陈 艳*, 李玉革   

  1. 新疆医科大学公共卫生学院卫生毒理学教研室，新疆 乌鲁木齐 830011
  • 收稿日期:2010-12-02 修回日期:2011-03-31 出版日期:2011-07-30 发布日期:2011-07-30
  • 通讯作者: 陈 艳

Mutagenic research on hair dyes Henna

TIAN Wei，HUANG Yun-fei，CHEN Yan*，LI Yu-ge   

  1. Toxicology Laboratory of Public Health College, Xinjiang Medical University, Urumqi 830011, Xinjiang, China
  • Received:2010-12-02 Revised:2011-03-31 Online:2011-07-30 Published:2011-07-30
  • Contact: CHEN Yan

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摘要： 目的： 探讨新疆特有染发剂海娜粉的致突变性。方法：采用小鼠骨髓细胞微核试验及精子畸形试验，检测海娜粉的致突变性。结果：小鼠骨髓细胞微核试验，海娜粉高、中、低剂量组 (分别为5 000、2 500、1 250 mg/kg)和阴性对照组 (蒸馏水)微核率分别为0.8‰、1.0‰、0.9‰和0.8‰，海娜粉各剂量组微核率与阴性对照组比较差异均无统计学意义 (P均＞0.05)。小鼠精子畸形试验，高、中、低剂量组和阴性对照组精子畸形率分别为1.4%、1.6%、1.4%和1.3%；海娜粉各剂量组精子畸形率与阴性对照比较组差异亦均无统计学意义 (P均＞0.05)。结论：在本实验条件下，未发现海娜粉的致突变性。

关键词: 海娜粉, 致突变性, 微核试验, 精子畸形试验

Abstract: OBJECTIVE: To assess the mutagenic effects of Henna，which is a special hair dye in Xinjiang. METHODS：Micronucleus test and sperm malformation test were performed to analyze the mutagenicity of Henna. RESULTS：The rates of micronuclei in three Henna groups (with concentrations of 5 000，2 500，1 250 mg/kg，respectively) and control group were 0.8‰，1.0‰，0.9‰ and 0.8‰，respectively. There was no significant difference between Henna groups and control group (P>0. 05). The rates of abnormal sperm in three Henna groups and control group were 1.4%，1.6%，1.4% and 1.3%，respectively. There was no significant difference between Henna groups and control group (P>0. 05). CONCLUSION：Henna showed no mutagenicity under this experimental condition.

Key words: Henna powder, mutagenicity, micronucleus test, sperm abnormality test

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