菊花浸膏对大鼠的致畸毒性试验

doi:10.3969/j.issn.1004-616x.2012.05.017

›› 2012, Vol. 24 ›› Issue (5): 386-388.doi: 10.3969/j.issn.1004-616x.2012.05.017

菊花浸膏对大鼠的致畸毒性试验

王凤岩;陈瑞仪;周轶琳;张紫虹;谭剑斌;杨美玲;胡帅尔;李欣

( 广东省疾病预防控制中心卫生毒理所，广东广州 510300 )

收稿日期:2011-11-22 修回日期:2012-02-15 出版日期:2012-09-30 发布日期:2012-09-30
通讯作者: 王凤岩

Study on teratogenicity of Chrysanthemum indicum extract in SD rats

WANG Feng-yan;CHEN Rui-yi; ZHOU Yi-lin;ZHANG Zi-hong; TAN Jian-bin; YANG Mei-ling;HU Shuai-er;LI Xin

(Guangdong Provincial Center for Disease Prevention and Control, Guangzhou 510300, Guangdong, China)

Received:2011-11-22 Revised:2012-02-15 Online:2012-09-30 Published:2012-09-30
Contact: WANG Feng-yan

摘要/Abstract

摘要： 目的：研究菊花浸膏对SD大鼠的胚胎毒性与致畸毒性。方法：孕SD鼠分为4组，分别为菊花浸膏0.68、2.03、6.09 g/kg剂量组和对照组，每组15～16只。实验组于受孕的第7～16天连续灌胃给予菊花浸膏，每天1次，对照组灌胃给予同体积纯净水，实验期间记录孕鼠的一般状况、体质量，于受孕第20天剖检孕鼠，检查孕鼠的体质量及妊娠情况，胎鼠的胎盘质量、体质量、身长与外观、骨骼、内脏的畸形情况。结果：菊花浸膏各剂量组孕鼠增重、活胎率、吸收胎率、活胎体质量及身长与对照组比较，差异均无统计学意义(P＞0.05)；菊花浸膏各剂量组胎鼠的外观、骨骼及内脏未见畸形。结论：在本实验条件下，未发现菊花浸膏对SD大鼠的胚胎毒性和致畸毒性。

关键词: 菊花浸膏, 胚胎毒性, 致畸作用, SD大鼠

Abstract: OBJECTIVE: To study the embryo toxicity and teratogenecity of Chrysanthemum indicum extract in SD rats. METHODS：SD rats successfully impregnated were divided into 4 groups (15-16 animals per group)，included three Chrysanthemum indicum extract dosage groups (0.68，2.03，6.09 g/kg) and one negative control group. During gestation from 7-16 days，animals were orally gavaged with Chrysanthemum indicum ectract once daily，clinical manifestations and weight of the pregnant rats were collected during the study. On the 20th day pregnant rats were euthanized and the weight of placenta，body weight and length of fetus and the appearance，visceral and skeletal malformations of fetus were examined. RESULTS：No statistically significant difference was found in all the assessed indices(including the weight gain of pregnant rats，average live fetus，absorptive fetus ratio，body weight and length of fetus) between dosage and control groups (P＞0.05). CONCLUSION：Under our experimental conditions，chrysanthemum indicum extract showed no significant effects in the toxicity of SD pregnant rats，had no apparent teratogenicity and embryotoxicity.

Key words: Chrysanthemum indicum extract, embryotoxicity, teratogenicity, SD rats

王凤岩;陈瑞仪;周轶琳;张紫虹;谭剑斌;杨美玲;胡帅尔;李欣. 菊花浸膏对大鼠的致畸毒性试验[J]. , 2012, 24(5): 386-388.

WANG Feng-yan;CHEN Rui-yi; ZHOU Yi-lin;ZHANG Zi-hong; TAN Jian-bin; YANG Mei-ling;HU Shuai-er;LI Xin. Study on teratogenicity of Chrysanthemum indicum extract in SD rats[J]. , 2012, 24(5): 386-388.

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菊花浸膏对大鼠的致畸毒性试验

Study on teratogenicity of Chrysanthemum indicum extract in SD rats

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