癌变·畸变·突变 ›› 2003, Vol. 15 ›› Issue (4): 231-233.doi: 10.3969/j.issn.1004-616x.2003.04.014

• 检测研究 • 上一篇    下一篇

益母草对小鼠遗传物质损伤的影响

朱玉琢1,庞慧民1,李秀东2,邢沈阳3,高久春1   

  1. 1.吉林大学基础医学院医学遗传学教研室; 2.吉林大学公共卫生学院毒理学教研室; 3.吉林大学护理学院生物学教研室,吉林 长春 130021
  • 收稿日期:2003-06-10 修回日期:2003-07-21 出版日期:2003-10-30 发布日期:2003-10-30
  • 通讯作者: 朱玉琢

INFLUENCE OF HERBA LOENURI ON THE GENETIC DAMAGE IN MICE

ZHU Yu-zhuo1,PANG Hui-min1, LI Xiu-dong2, et al   

  1. 1.Department.of Medical Genetics, School of Basic Medical Sciences,Jilin University,Changchun 130021,China;2. Department of Toxicology,School of preventive Medicine,Jilin University,Changchun 130021,China; 3.Department of Biology ,College of Nursing,Jilin University ,Changchun 130021,China
  • Received:2003-06-10 Revised:2003-07-21 Online:2003-10-30 Published:2003-10-30
  • Contact: ZHU Yu-zhuo

摘要: 目的:观察中草药益母草对醋酸铅引起的小鼠遗传物质损伤的影响。方法:采用小鼠骨髓微核试验和小鼠精子畸形试验。结果:益母草本身不能诱发小鼠骨髓微核和小鼠精子畸形,但在与醋酸铅一同给药时,可使醋酸铅所诱发的小鼠骨髓微核和小鼠精子畸形频率明显降低。结论:益母草对小鼠遗传物质具有保护作用,即抗诱变作用。

关键词: 益母草, 醋酸铅, 微核, 精子畸形, 遗传损伤, 抗诱变

Abstract: Purpose:To observe the influence of herba loenuri on the genetic damage induced by Pb(CH3COO)2 in mice. Methods:The micronucleus test of mouse bone marrow cell and sperm abnormality test in mice were used in this study. Results: Herba loenuri could not induce either micronucleus formation in the mouse bone marrow cells or sperm abnormality in mice, but the frequencies of micronucleus formation in the mouse bone marrow cells and sperm abnormality in mice indued by Pb(CH3COO)2 were reduced significantly if herba loenuri and Pb(CH3COO)2 were given stimultaneously. Conclusion: Herba loenuri showed a protective effect ,namely antimutagenesis ,on genetic materials in mice.

Key words: herba loenuri, Pb(CH3 COO)2, micronucleus formation, sperm abnormality, genetic damage, antimutagenesis