癌变·畸变·突变 ›› 2007, Vol. 19 ›› Issue (5): 416-417.doi: 10.3969/j.issn.1004-616x.2007.05.020

• 检测研究 • 上一篇    下一篇

吊白块急性毒性作用研究

周 颖/ 朱 伟/ 杜琰琰/ 张全新   

  1. (广州市疾病预防控制中心毒理科,广东 广州 510080)
  • 收稿日期:2006-09-25 修回日期:2007-05-17 出版日期:2007-09-30 发布日期:2007-09-30
  • 通讯作者: 朱 伟

Acute Toxicity of Sodium Formaldehyde Sulfoxylate

ZHOU Ying, ZHU Wei, DU Yan_yan, ZHANG Quan_xin   

  1. (Department of Toxicology, Guangzhou Center for Disease Control and Prevention, Guangzhou 510080, China)
  • Received:2006-09-25 Revised:2007-05-17 Online:2007-09-30 Published:2007-09-30
  • Contact: ZHU Wei

摘要: 背景与目的: 确定吊白块半数致死剂量LD50 。 材料与方法: 采用改进寇氏法测定吊白块LD50。 结果: 吊白块对NIH小鼠经口灌胃LD50为8 711 mg/kg。 结论: 根据国家标准评价,吊白块毒性分级属实际无毒级。

关键词: 吊白块, 急性毒性, 半数致死浓度

Abstract: BACKGROUND & AIM: To find the median lethal dose of sodium formaldehyde sulfoxylate(SFS). MATERIALS AND METHODS: 50 NIH male mice were fed normal food and water before test and were randomly dividecl into five groups treated with SFS at different doses by gavage. The indices included toxic syndrome and death rate in each group. RESULTS: The lethal dose of SFS was 8 711 mg/kg. CONCLUSION: SFS actually belonged to the non_toxic grade by national criteria of toxins.

Key words: sodium formaldehyde sulfoxylate(SFS), acute toxicity, LD50

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