蛋白磷酸酶2A调控细胞周期发挥抗肿瘤作用的研究进展

doi:10.3969/j.issn.1004-616x.2016.02.016

癌变·畸变·突变 ›› 2016, Vol. 28 ›› Issue (2): 155-157,161.doi: 10.3969/j.issn.1004-616x.2016.02.016

蛋白磷酸酶2A调控细胞周期发挥抗肿瘤作用的研究进展

庄群瑛, 林育纯, 林忠宁

厦门大学公共卫生学院, 分子疫苗学和分子诊断学国家重点实验室, 福建厦门 361102

收稿日期:2015-11-20 修回日期:2016-01-18 出版日期:2016-03-31 发布日期:2016-03-31
通讯作者: 林忠宁,E-mail:linzhn@xmu.edu.cn E-mail:linzhn@xmu.edu.cn
作者简介:庄群瑛,E-mail:672678722@qq.com
基金资助:
国家自然科学基金(81172705,81472997,81573181);973计划前期研究专项(2014CB560710);福建省自然科学基金项目(2014J01372,2015J01344);厦门大学山海基金项目(2013SH007)

Received:2015-11-20 Revised:2016-01-18 Online:2016-03-31 Published:2016-03-31

摘要/Abstract

摘要： 蛋白磷酸酶2A(PP2A)是真核细胞内广泛表达的丝氨酸/苏氨酸蛋白磷酸酶家族的主要成员,参与细胞周期、增殖分化及凋亡等过程中信号通路的去磷酸化调控。研究表明,PP2A不同亚基表达调控与人群肿瘤风险存在关联性;PP2A与细胞周期相关激酶相互作用,二者调控平衡的研究有助于致癌机制的探讨和靶向PP2A抗肿瘤作用的探索。本文对PP2A调控细胞周期的研究进行综述,着重阐述PP2A-B亚基经由细胞周期因子依赖性激酶1(CDK1)调控细胞周期发挥抑癌作用的机制,为肿瘤的化学预防和靶向干预提供理论依据。

关键词: 蛋白磷酸酶2A, 抗癌作用, 细胞周期, 细胞周期因子依赖性激酶1

中图分类号:

R730.231

庄群瑛, 林育纯, 林忠宁. 蛋白磷酸酶2A调控细胞周期发挥抗肿瘤作用的研究进展[J]. 癌变·畸变·突变, 2016, 28(2): 155-157,161.

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蛋白磷酸酶2A调控细胞周期发挥抗肿瘤作用的研究进展

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