绝经后妇女尿液中微量元素与骨质疏松症的相关性研究

doi:10.3969/j.issn.1004-616x.2025.06.007

癌变·畸变·突变 ›› 2025, Vol. 37 ›› Issue (6): 467-472.doi: 10.3969/j.issn.1004-616x.2025.06.007

• 论著 • 上一篇

绝经后妇女尿液中微量元素与骨质疏松症的相关性研究

叶铭琪^1,2, 周涛³, 刘佩意², 罗毅⁴, 刘建军^1,2, 黄振烈¹, 任晓虎^1,2

1. 南方医科大学公共卫生学院毒理学系/国家药监局化妆品安全评价重点实验室/广东省热带病重点实验室, 广东广州 510080;
2. 深圳市疾病预防控制中心深圳市现代毒理学重点实验室, 广东深圳 518000;
3. 中山大学公共卫生学院(深圳), 广东深圳 518000;
4. 罗湖区中医院康复分院, 广东深圳 518000

收稿日期:2025-02-10 修回日期:2025-09-09 发布日期:2025-12-06
通讯作者: 任晓虎，E-mail：slim54@126.com;黄振烈，E-mail：huangzhenlie858252@smu.edu.cn
作者简介:叶铭琪，E-mail：makie1209@smu.edu.cn。
基金资助:
国家自然科学基金(82373572，82003430)；深圳市基础研究项目(JCYJ20210324140614040)；深圳市医学重点学科建设项目(SZXK069)；深圳市医疗卫生三名工程项目(SZSM202211010)

Association between urinary trace elements and osteoporosis in postmenopausal women

YE Mingqi^1,2, ZHOU Tao³, LIU Peiyi², LUO Yi⁴, LIU Jianjun^1,2, HUANG Zhenlie¹, REN Xiaohu^1,2

1. Department of Toxicology, School of Public Health, Southern Medical University/Key Laboratory of Cosmetic Safety Evaluation, National Medical Products Administration/Key Laboratory of Tropical Diseases in Guangdong Province, Guangzhou 510080;
2. Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Center for Disease Control and Prevention, Shenzhen 518000;
3. School of Public Health, Sun Yat-sen University (Shenzhen), Shenzhen 518000;
4. Rehabilitation Branch of Luohu District Hospital of Traditional Chinese Medicine, Shenzhen 518000, Guangdong, China

Received:2025-02-10 Revised:2025-09-09 Published:2025-12-06

摘要/Abstract

摘要： 目的：探讨绝经后妇女尿液中微量元素与骨质疏松症发病风险的关联。方法：基于横断面研究，从深圳老年相关疾病队列中选取3 667名绝经后妇女作为研究对象，通过标准化问卷收集人口学特征信息，并使用超声骨密度仪评估跟骨密度水平。通过电感耦合等离子体质谱法(ICP-MS)检测尿液样本中22种微量元素的浓度，所有检测均经过严格的质量控制。使用多因素logistic回归分析和基于分位数的g计算评估尿液中微量元素水平与骨质疏松症风险的关联。结果：绝经后妇女尿液中微量元素铬、铜、锌、硒、钼、钒、锂、钛、铷、锡、钡与骨质疏松症发病风险相关联，属于危险因素(OR在1.07~2.39之间，均为P<0.01)，而钴、锑与骨质疏松症发病风险呈负性关联，属于保护因素(OR分别为0.80、0.81，P<0.01)。混合效应分析显示，必需微量元素和可能必需微量元素的联合作用与骨质疏松症风险存在统计学相关性(OR分别为1.15、1.13，P<0.01)。结论：本研究发现不同的微量元素可能对绝经后妇女骨质疏松症风险产生不同影响，提示微量元素代谢失衡可能在骨质疏松症发病中起重要作用。

关键词: 绝经后妇女, 微量元素, 代谢, 骨质疏松症

Abstract: OBJECTIVE：To investigate associations between urinary trace elements and osteoporosis risk in postmenopausal women in Shenzhen. METHODS：Based on a cross-sectional study，3 667 postmenopausal women were selected from the Shenzhen Aging-Related Diseases Cohort as participants. Demographic characteristics were collected via standardized questionnaires，and calcaneal bone mineral density (BMD) was assessed using quantitative ultrasound. Urinary concentrations of 20 trace elements were measured by inductively coupled plasma mass spectrometry (ICP-MS)，with all assays undergoing rigorous quality control. Multivariable logistic regression and quantile-based g-computation were employed to evaluate associations between urinary trace element levels and osteoporosis risk. RESULTS：Chromium (Cr)，copper (Cu)，zinc (Zn)，selenium (Se)，molybdenum (Mo)，vanadium (V)，lithium (Li)，titanium (Ti)，rubidium (Rb)，tin (Sn)，and barium (Ba) showed positive associations with osteoporosis risk (OR=1.41，2.33，1.35，1.36，1.34，1.62，1.07，2.39，1.42，1.48，and 1.56，respectively；all P<0.01). In contrast，cobalt (Co) and antimony (Sb) were negatively associated with osteoporosis risk (OR=0.80 and 0.81，respectively；P<0.01). Mixed-effect analysis revealed statistically significant joint effects of essential trace elements and potentially essential trace elements on osteoporosis risk (OR=1.15 and 1.13，respectively；P<0.01). CONCLUSION：This study found that different trace elements exerted distinct associations with osteoporosis risk in postmenopausal women，suggesting that imbalances in trace element metabolism may play a significant role in the pathogenesis of osteoporosis.

Key words: postmenopausal women, trace element, metabolism, osteoporosis

中图分类号:

R181

叶铭琪, 周涛, 刘佩意, 罗毅, 刘建军, 黄振烈, 任晓虎. 绝经后妇女尿液中微量元素与骨质疏松症的相关性研究[J]. 癌变·畸变·突变, 2025, 37(6): 467-472.

YE Mingqi, ZHOU Tao, LIU Peiyi, LUO Yi, LIU Jianjun, HUANG Zhenlie, REN Xiaohu. Association between urinary trace elements and osteoporosis in postmenopausal women[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2025, 37(6): 467-472.

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绝经后妇女尿液中微量元素与骨质疏松症的相关性研究

Association between urinary trace elements and osteoporosis in postmenopausal women

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