p53 及PCNA 的异常表达在食管上皮增生和癌变过程中的意义

doi:10.3969/j.issn.1004-616x.2002.02.006

癌变·畸变·突变 ›› 2002, Vol. 14 ›› Issue (2): 87-090.doi: 10.3969/j.issn.1004-616x.2002.02.006

p53 及PCNA 的异常表达在食管上皮增生和癌变过程中的意义

陶仪声1 ; 宗永生2

1. 蚌埠医学院病理教研室,安徽　蚌埠　233003 ; 　2. 中山医科大学病理教研室,广东　广州　510089

收稿日期:2001-09-17 修回日期:2001-10-09 出版日期:2002-04-30 发布日期:2002-04-30
通讯作者: 陶仪声

THE SIGNIFICANCE OF OVER-EXPRESSION OF p53 PROTEIN AND PROLIFERATION CELL NUCLEAR ANTIGEN IN ESOPHAGEAL EPITHELIOSIS AND CARCINOGENESIS

TAO Yi-sheng1 , ZON G Yong-sheng2

1. Department of Pathology , Bengbu Medical College , Bengbu 233003 ; 2. Departmant of Pathology , Sun Yat-Sen University of Medical Sciences , Guangzhou 510089 , China

Received:2001-09-17 Revised:2001-10-09 Online:2002-04-30 Published:2002-04-30
Contact: TAO Yi-sheng

摘要/Abstract

摘要： 目的:研究食管上皮增生、不典型增生及原位癌中p53 蛋白及增殖细胞核抗原(PCNA) 的异常表达,探讨其在食管癌发生发展中的作用。方法:用免疫组化LSAB 方法检测189 例食管鳞癌癌旁上皮及原位癌中p53 及PCNA 的表达。结果:癌旁上皮中存在p53 蛋白积聚,从上皮增生→不典型增生→原位癌,其阳性率依次为55 %、79 %和98 %( P < 0. 01) 。PCNA 的阳性强度也是依次递增。结论:p53 蛋白的积聚在食管鳞癌癌前病变中既已存在,说明它是一个早期事件,在食管癌的发生中起一定的作用。p53 及PCNA 的异常表达可能成为判断食管上皮发生癌变或癌前病变的客观指标之一。

关键词: p53 蛋白, 增殖细胞核抗原(PCNA), 食管上皮, 不典型增生, 原位癌

Abstract: Purpose : To study the over-expression of p53 protein and proliferation cell nuclear antigen (PCNA) in human esophageal basal cell hyperplasia , atypical hyperplasia , and carcinoma in situ , and to analyse the significance of the expression. Methods : 189 specimen of esophageal paracarcinoma epithelia and cancinoma in situ were tested for p53 and PCNA using immunohistochemical technic. Results : From basal cell hyperplasia to atypical hyperplasia to cancinoma in situ , the rates of p53 protein accumulation were 55 % , 79 % and 98 % ( P <0. 01) , respectively , and PCNA immunostain-positive cells increased in number as well. Conclusions : p53 protein accumulation occurs early in the pathogenesis of esophageal carcinoma. Over-expression of p53 protein and PCNA may serve as an indicator of precancerous lesions and malignancy in the human esophageal epithelium.

Key words: p53 protein, proliferation cell nuclear antige (PCNA), esophageal epithelium, atypical hyperplasia, carcinoma in situ

中图分类号:

R730. 2

陶仪声 , 宗永生. p53 及PCNA 的异常表达在食管上皮增生和癌变过程中的意义[J]. 癌变·畸变·突变, 2002, 14(2): 87-090.

TAO Yi-sheng , ZON G Yong-sheng. THE SIGNIFICANCE OF OVER-EXPRESSION OF p53 PROTEIN AND PROLIFERATION CELL NUCLEAR ANTIGEN IN ESOPHAGEAL EPITHELIOSIS AND CARCINOGENESIS[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2002, 14(2): 87-090.

[1]	肖红梅, 吴逸, 张婷, 王少康, 孙桂菊. 微囊藻毒素-LR对人正常食管上皮细胞凋亡及对Caspase-3和Caspase-9蛋白表达的影响[J]. 癌变·畸变·突变, 2017, 29(6): 418-421,426.
[2]	徐漪, 李旭峰, 张慧霞, 陈艳. DNMT1高表达在MNNG诱导哈萨克族食管上皮细胞恶性转化中的作用[J]. 癌变·畸变·突变, 2017, 29(6): 460-466.
[3]	陈艳, 张慧霞. 基于TALE技术的哈萨克族食管上皮DNA甲基转移酶1高表达细胞株模型的构建[J]. 癌变·畸变·突变, 2016, 28(6): 428-431,437.
[4]	李旭峰, 张慧霞, 凯德丽艳·阿布都外力, 陈艳. 叶酸在MNNG影响哈萨克族食管上皮细胞DNMT1酶活性及表达中的作用[J]. 癌变·畸变·突变, 2016, 28(6): 458-463.
[5]	尹东，黄思语，陈艳. 甲基硝基亚硝基胍对哈萨克族人群正常食管上皮细胞p16 和 FHIT 基因甲基化及其表达的影响[J]. 癌变·畸变·突变, 2014, 26(5): 353-356.
[6]	吴名耀/吴贤英/李乔山/郑瑞明. Egr-1和PTEN蛋白的表达在食管上皮增生和癌变过程中的意义[J]. 癌变·畸变·突变, 2006, 18(4): 320-322.
[7]	杨　蕾, 高　歌, 赵建军, 盛传伦. COX-2在胃癌组织中的表达及与Hp感染的关系探讨[J]. 癌变·畸变·突变, 2003, 15(3): 147-149.
[8]	吴名耀, 吴贤英, 庄楚香. hTRT和C-myc的表达在食管上皮增生和癌变过程中的意义[J]. 癌变·畸变·突变, 2003, 15(1): 17-20.

p53 及PCNA 的异常表达在食管上皮增生和癌变过程中的意义

THE SIGNIFICANCE OF OVER-EXPRESSION OF p53 PROTEIN AND PROLIFERATION CELL NUCLEAR ANTIGEN IN ESOPHAGEAL EPITHELIOSIS AND CARCINOGENESIS

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 8

编辑推荐

Metrics

本文评价