端粒蛋白复合物shelterin的结构及功能研究进展

doi:10.3969/j.issn.1004-616x.2019.03.015

癌变·畸变·突变 ›› 2019, Vol. 31 ›› Issue (3): 253-256.doi: 10.3969/j.issn.1004-616x.2019.03.015

端粒蛋白复合物shelterin的结构及功能研究进展

王晗¹, 倪娟^1,2, 薛京伦³, 汪旭^1,2

1. 云南师范大学生命科学学院, 云南昆明 650500;
2. 云南师范大学生物能源持续开发与利用教育部工程研究中心, 云南昆明 650500;
3. 复旦大学生命科学学院, 上海 200433

收稿日期:2018-10-20 修回日期:2019-04-25 出版日期:2019-05-31 发布日期:2019-05-31
通讯作者: 汪旭,E-mail:wangxu@fudan.edu.cn E-mail:wangxu@fudan.edu.cn
作者简介:王晗,E-mail:wanghan9215@163.com。
基金资助:
国家自然科学基金（31860301）；台州市领军型创新创业团队基金

Received:2018-10-20 Revised:2019-04-25 Online:2019-05-31 Published:2019-05-31

摘要/Abstract

摘要： 端粒是稳固真核生物染色体末端、保护遗传信息完整的必要组分，端粒酶、端粒蛋白复合物（shelterin）等与端粒相互作用的蛋白因子，均参与端粒结构和功能的维持。其中，shelterin复合物可通过特异结合到端粒区，帮助端粒成帽，在调控端粒长度、维护端粒结构和功能完整性方面发挥重要作用。Shelterin复合物6种核心蛋白组分的结构及其端粒维护功能的研究，对端粒生物学、端粒相关的退行性疾病研究具有重要意义，各组分表达异常或结构改变与端粒功能失调、细胞衰老加速相关，将导致基因组不稳定性以及疾病发生。本文对shelterin复合物的结构和各组分的功能研究进展进行综述。

关键词: 端粒蛋白复合物, shelterin, 端粒保护蛋白1, POT1结合蛋白1, TRF相互作用蛋白

中图分类号:

王晗, 倪娟, 薛京伦, 汪旭. 端粒蛋白复合物shelterin的结构及功能研究进展[J]. 癌变·畸变·突变, 2019, 31(3): 253-256.

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端粒蛋白复合物shelterin的结构及功能研究进展

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