苯丙(a)蒽的毒性研究进展

doi:10.3969/j.issn.1004-616x.2021.02.011

摘要/Abstract

摘要： 苯丙（a）蒽（BaA）是一种四环结构的多环芳烃（PAH）类物质，是化石燃料不完全燃烧的副产物，与其他的PAHs以混合物的形式存在。BaA可通过口腔、鼻腔及皮肤等多种途径暴露于人类，对人的主要危害是致癌性。国际癌症研究机构（IARC）根据其分类标准将BaA归为2B类（对人可能致癌）。目前尚无充足数据支持通过计算剂量外推斜率因子（slope factor）来完成动物致癌系数与人体致癌系数之间的推导。本文对BaA的致癌性等毒性研究进行系统文献检索与综述，以期为今后进行BaA的健康风险评估提供可靠的毒理学数据基础。

关键词: 苯丙(a)蒽, 致癌性, 遗传毒性, 生态毒性

中图分类号:

R994.6

敬海明, 李国君, 宁钧宇. 苯丙(a)蒽的毒性研究进展[J]. 癌变·畸变·突变, 2021, 33(2): 149-152.

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