人体痛风石中微塑料的定性与定量分析

doi:10.3969/j.issn.1004-616x.2023.05.006

癌变·畸变·突变 ›› 2023, Vol. 35 ›› Issue (5): 360-365,373.doi: 10.3969/j.issn.1004-616x.2023.05.006

人体痛风石中微塑料的定性与定量分析

黄育斌¹, 吕全伟²

1. 汕头市龙湖区长平路153号, 广东汕头 515057;
2. 汕头市医学科学院, 广东汕头 515031

收稿日期:2023-08-21 修回日期:2023-09-19 发布日期:2023-10-13
作者简介:黄育斌,E-mail:chgdsthl@163.com

Qualitative and quantitative analysis of microplastics in human tophi

HUANG Yubin¹, Lü Quanwei²

1. No.153, Changping Road, Longhu Distirict, Shantou 515057;
2. Shantou Academy of Medical Sciences, Shantou 515031, Guangdong, China

Received:2023-08-21 Revised:2023-09-19 Published:2023-10-13

摘要/Abstract

摘要： 目的： 检测微塑料是否存在于人体的痛风石中，并对检出的微塑料进行定性及定量分析，以进一步阐明痛风石的组成，探讨微塑料于关节处痛风石形成过程中可能起到的作用，为痛风治疗提供新思路。方法： 收集5名男性痛风患者(血尿酸浓度>500 μmol/L)的痛风石样品，采用热解-气相色谱/质谱法(Py-GC/MS)对痛风石中可能存在的10种微塑料成分进行检测分析。结果： 4名患者的痛风石内检出大于或等于1种微塑料，共计4种不同类型的微塑料(聚苯乙烯、聚乙烯、聚氯乙烯、聚己二酰己二胺)被检出，且结果显示聚苯乙烯及聚乙烯二者检出率最高，平均含量分别为20.300和115.157 mg/kg。结论： 微塑料可以在人体痛风石中被检出，其可能参与人体痛风石的形成。

关键词: 微塑料, 痛风石, 痛风, 健康风险

Abstract: OBJECTIVE:This study aimed at detecting whether microplastics existed in human tophi; and then qualitatively and quantitatively analyzing the detected microplastics; identifying compositions of tophi,exploring possible roles of microplastic accumulation in tophi formation in the joints,and then providing new ideas for the treatment of gout. METHODS: Samples of gouty tophus from 5 male patients (serum uric acid>500 μmol/L) were included for analysis,and pyrolysis-gas chromatography-mass spectrometry (Py-GC/MS) was used to detect 10 types of microplastics that might exist in tophi. RESULTS: More than or equal to 1 type of microplastic was detected in the tophi of 4 patients,and a total of 4 different types of microplastics (polystyrene,polyethylene,polyvinyl chloride,polyadiohexylenediamine) were identified. The results demonstrate that polystyrene (PS) and polyethylene (PE) had the highest detection rate,with average contents of 20.300 and 115.157 mg/kg,respectively. CONCLUSION: Microplastics can be detected in human tophi,which may be involved in and may play a certain role in the formation of human tophi.

Key words: microplastic, tophus, gout, health risks

中图分类号:

R994.6

黄育斌, 吕全伟. 人体痛风石中微塑料的定性与定量分析[J]. 癌变·畸变·突变, 2023, 35(5): 360-365,373.

HUANG Yubin, Lü Quanwei. Qualitative and quantitative analysis of microplastics in human tophi[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2023, 35(5): 360-365,373.

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人体痛风石中微塑料的定性与定量分析

Qualitative and quantitative analysis of microplastics in human tophi

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