癌变·畸变·突变 ›› 2006, Vol. 18 ›› Issue (6): 459-461.doi: 10.3969/j.issn.1004-616x.2006.06.012

• 论著 • 上一篇    下一篇

食管早期鳞癌的神经内分泌分化及其意义

杜　芸；杨会钗；王永军；王小玲；吴国祥；左连富   

  1. 河北省肿瘤医院病理科
  • 收稿日期:2005-11-02 修回日期:2005-12-23 出版日期:2006-11-30 发布日期:2006-11-30
  • 通讯作者: 杜 芸

Neuroendocrine Differentiation and Its Significance in Early Esophageal Squamous Cell Carcinoma

DU Yun,WANG Yong-jun,YANG Hui-chai,WANG Xiao-ling,WU Guo-xiang, ZUO Lian-fu   

  1. (Pathology Department of Hebei Tumour Hospital，Shijiazhuang 050011，China)
  • Received:2005-11-02 Revised:2005-12-23 Online:2006-11-30 Published:2006-11-30
  • Contact: DU Yun

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摘要： 【摘要】 背景与目的： 探讨神经内分泌分化对早期食管鳞状细胞癌预后的意义。 材料与方法： 采用免疫组化的方法检测48例早期食管鳞状细胞癌神经内分泌指标CgA、Syn的表达情况及其与增殖指标PCNA及预后的关系。 结果: CgA、Syn在48例早期食管鳞状细胞癌中阳性表达率分别为33.3％，22.9％；CgA的阳性表达与食管鳞癌的浸润深度、分化无明显关系(P=0.601，0.091)。Syn的阳性表达与食管鳞癌的浸润深度无关(P=0.663)， 但与食管鳞癌的分化有关(P=0.033)。CgA、Syn的阳性表达与PCNA相关(r=0.299,P=0.039；r=0.288, P=0.047)。COX回归模型仅显示肿瘤的分化和浸润深度为独立的预后指标。结论: 本研究显示神经内分泌分化与早期食管鳞状细胞癌的预后无明显相关性, 不能作为估计预后的指标。

关键词: 食管癌, 神经内分泌分化, CgA, Syn

Abstract: 【ABSTRACT】 BACKGROUND ＆AIM： Study prognostic significance of neuroendine(NE) differentiation in early esophageal squamous cell carcinoma(ESCC). MATERIALS AND METHODS： Expressions of CgA，Syn and PCNA in 48 cases of ESCC were detected by immunohistochemistry， and their prognostic significances in early ESCC were studied. RESULTS： Positive rates of CgA and Syn were 33.3％ and 22.9％, respectively. Expression of CgA was not correlated with the depth of invasion and differentiation(P=0.601, 0.091). Expression of Syn was not correlated with the depth of invasion (P=0.663), but correlated with differentiation(P=0.033).CgA and Syn were correlated with PCNA(rs=0.299, P=0.039; rs=0.288, P=0.047).Cox regression revealed that only tumor differentiation and the depth of invasion were independent prognostic factors. CONCLUSION： There was no correlation between NE differentiation and prognosis of ESCC.

Key words: esophageal cancer, neuroendocrine differentiation, CgA, Syn

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