二甲基甲酰胺、丁二烯作业工人细胞微核率及染色体断裂率的观察

doi:10.3969/j.issn.1004-616x.1998.03.010

癌变·畸变·突变 ›› 1998, Vol. 10 ›› Issue (3): 163-167.doi: 10.3969/j.issn.1004-616x.1998.03.010

二甲基甲酰胺、丁二烯作业工人细胞微核率及染色体断裂率的观察

王德启　艾晓清　董定龙　赵国华　郁　明　张建华　王　勇　张　宏

大庆职工医学院优生遗传研究所　大庆　163312

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1998-05-30 发布日期:1998-05-30

THE RESEARCH ON THE FREQUENCES OF MICRONUCLI AND CHROMOSOME BREAKS OF THE DIMETHYLFORMAMIDE AND BUTADIENE EXPOSED WORKERS

Wang Deqi , Ai Xiaoqing , Dong Dinglong , Zhao Guohua , Yu Ming , Zhang J ianhua , Wnag Yong , Zhang Hong

The Instit ute of Improving Bi rth Quality and Geneties of Daqing Medical College for Staff Members , Daqing 　163312

Received:1900-01-01 Revised:1900-01-01 Online:1998-05-30 Published:1998-05-30

摘要/Abstract

摘要： 探讨二甲基甲酰胺、丁二烯对作业工人遗传物质是否有损害。采用微核技术对二甲基甲酰胺、丁二烯作业工人64 人进行微核及染色体断裂率观察。工人的微核率、微核细胞率及染色体断裂率三项指标分别为14169 ‰、12140 ‰、1161 %均明显高于对照组( P < 0101) ) 。结论:二甲基甲酰胺、丁二烯对作业工人遗传物质具有损害作用。

关键词: 二甲基甲酰胺, 丁二烯, 遗传物质

Abstract: To study whether Dimethylformamide and Butadiene can damage the worker’genetic materials , the paper observed 64 Dimethylformamide and Butadiene exposed workers’frequences of micronucli using the micronucleus technique , and chromosome breaks using karyotyping analysis. Dimethylformamide and Butadiene exposed workers’micronucleus rate , micronucleus cell and chromosome breaks rate are 14. 69 ‰、12. 40 ‰、1. 61 % respectively , significantly higher than cont rol group ( P < 0. 01) . The result s showed that Dimethylformamide and Butadiene can damage workers , genetic materials.

Key words: Dimethylformamide, Butadiene, genetic materials

王德启　艾晓清　董定龙　赵国华　郁　明　张建华　王　勇　张　宏. 二甲基甲酰胺、丁二烯作业工人细胞微核率及染色体断裂率的观察[J]. 癌变·畸变·突变, 1998, 10(3): 163-167.

Wang Deqi , Ai Xiaoqing , Dong Dinglong , Zhao Guohua , Yu Ming , Zhang J ianhua , Wnag Yong , Zhang Hong. THE RESEARCH ON THE FREQUENCES OF MICRONUCLI AND CHROMOSOME BREAKS OF THE DIMETHYLFORMAMIDE AND BUTADIENE EXPOSED WORKERS[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 1998, 10(3): 163-167.

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二甲基甲酰胺、丁二烯作业工人细胞微核率及染色体断裂率的观察

THE RESEARCH ON THE FREQUENCES OF MICRONUCLI AND CHROMOSOME BREAKS OF THE DIMETHYLFORMAMIDE AND BUTADIENE EXPOSED WORKERS

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