癌变·畸变·突变 ›› 2003, Vol. 15 ›› Issue (4): 215-216.doi: 10.3969/j.issn.1004-616x.2003.04.008

• 论著 • 上一篇    下一篇

鳞癌与基底细胞癌的Fas/FasL表达及其与细胞凋亡的关系

杨开颜1,俞 康2,李剑敏1,黄卡特1   

  1. 1.温州医学院附属一院病理科,浙江 温州 325000 ;2.温州医学院附属一院血液科, 浙江 温州 325000
  • 收稿日期:2003-02-06 修回日期:2003-04-30 出版日期:2003-10-30 发布日期:2003-10-30
  • 通讯作者: 杨开颜

THE RELATIONSHIP BETWEEN Fas/FasL EXPRESSION IN SQUAMOUS CELL CARCINOMA,BASAL CELL CARCINOMA AND CELL APOPTOSIS

YANG Kai-yan1,YU Kang2,LI Jian-min1,et al   

  1. 1.Department of Pathology The First Hospital of Wenzhou Medical College , Wenzhou 325000, China. 2. Deaertment of Hematology The First A ffiliated Hospital of Wenzhou Medical College , Wenzhou 325000, China
  • Received:2003-02-06 Revised:2003-04-30 Online:2003-10-30 Published:2003-10-30
  • Contact: YANG Kai-yan

摘要: 目的:探讨鳞癌与基底细胞癌的Fas/FasL表达及其与细胞凋亡的关系。方法: 用免疫组化及TUNEL方法检测45例鳞癌与基底细胞癌的Fas/FasL表达及其与细胞凋亡的关系。结果: 鳞癌Fas/FasL表达高于基底细胞癌;Fas/FasL阳性细胞凋亡率高于阴性细胞。 结论: Fas/FasL系统与细胞凋亡密切相关,并在肿瘤侵袭中可能起重要作用。

关键词: 鳞状细胞癌, 基底细胞癌, 凋亡, Fas/FasL

Abstract: Purpose: To explore the relationship between Fas/FasL expression in squamous cell carcinoma, basal cell carcinoma or cell apoptosi. Methods: Fas/FasL expression and cell apoptosis were studied in 45 patients suffering from squamous cell carcinoma or basal cell carcinoma by immunohistochemistry and terminal deoxynucleotidyl transferase-mediated dUTP-DIG nick end labeling (TUNEL). Results: Fas/FasL expression in squamous cell carcinoma was higher than in basal cell carcinoma. The apoptosis rate of Fas/FasL positive cells was higher than that of Fas/FasL negative cells. Conclusion: Fas/FasL system was rather associated with cell apoptosis and may play an important role in tumor invasion.

Key words: squamous cell carcinoma, basal cell carcinoma, apoptosis, Fas/FasL