刺五加在小鼠实验性肺癌侵袭转移过程中作用

doi:10.3969/j.issn.1004-616x.2005.04.007

癌变·畸变·突变 ›› 2005, Vol. 17 ›› Issue (4): 217-219.doi: 10.3969/j.issn.1004-616x.2005.04.007

刺五加在小鼠实验性肺癌侵袭转移过程中作用

张敬一; 许顺江; 杨惠敏

河北省疾病预防控制中心，河北　石家庄　050021

收稿日期:2004-02-10 修回日期:2004-06-10 出版日期:2005-07-30 发布日期:2005-07-30
通讯作者: 张敬一

Experimental Study on the Anticancer Role of Acanthopanax Senticosus in the Invasion and Metastasis Process

ZHANG Jing-yi; XU Shun-jiang; YANG Hui-min

Hebei Province Center for Disease Prevention and Control,Shijiazhuang 050021,Hebei,China

Received:2004-02-10 Revised:2004-06-10 Online:2005-07-30 Published:2005-07-30
Contact: ZHANG Jing-yi

摘要/Abstract

摘要： 背景与目的：探讨刺五加对小鼠Lewis肺癌侵袭转移干预作用的效果。材料与方法： Lewis肺癌C57/BL雌性小鼠分成刺五加＋环磷酰胺组、环磷酰胺组、刺五加组和肿瘤组，通过检测各组小鼠的瘤重和抑瘤率，应用酶联免疫吸附试验(Enzyme-linked immunosorbent assay,ELISA)法检测血浆、瘤和肺组织中I型纤溶酶原激活剂抑制剂(Plasminogen activator inhibitor-Ⅰ,PAI-1)、尿激酶型纤溶酶原激活剂(uroleinase type Plasminogen Activator,uPA)活性观察刺五加对Lewis肺癌的干预作用。结果：刺五加较肿瘤组瘤重、血浆和瘤，肺组织PAI-1、uPA活性明显降低。结论：刺五加有抑制肿瘤生长、减少瘤、肺组织和血浆中uPA、PAI-1活性，对实验性小鼠肺癌侵袭转移过程中显示出了一定的干预作用。刺五加适于被开发为常规抗癌辅助药物。刺五加＋环磷酰胺组的效果比单独一组药的效果更好。

关键词: 刺五加, 抗癌转移作用, Lewis肺癌, Ⅱ型纤深酶原激活剂抑制剂, 悄激酶型行溶酶原激活剂

Abstract: BACKGROUND ＆ AIM: To study the intervene role of acanthopanax sentiocosus (APS) in mice Lung during mice Lewis lung cancer. MATERIAL AND METHODS: Lewis lung cancer C57/BL mice were divided into acanthopanax senticasus＋cyclophosphemide(CP),cyclophosphemide, acanthopanax sentiocosus and tumor groups.The tumor weight and inhibitory rate of each group were detected by elisa,PAI-1 and uPA activation. RESULTS: The content of PAI-1,uPA of plasma and tumor, lung of APS group mice was significantly lower than tumor group in each time. CONCLUSION: APS exhibited intervention effects on the invasion and metastasis of cancer, and mice in APS plus CP group were getting better than APS alone group and CP alone group.

Key words: acanthopanax senticosus, anticancer metastasis action, lewis lung cancer, plasminogen activator inhibitor Ⅰ, uroleinase type plasminogen activator

张敬一, 许顺江, 杨惠敏. 刺五加在小鼠实验性肺癌侵袭转移过程中作用[J]. 癌变·畸变·突变, 2005, 17(4): 217-219.

ZHANG Jing-yi, XU Shun-jiang, YANG Hui-min. Experimental Study on the Anticancer Role of Acanthopanax Senticosus in the Invasion and Metastasis Process[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2005, 17(4): 217-219.

[1]	乔田奎, 袁素娟, 陈伟, 庄喜兵. CpG ODN对卡铂治疗Lewis肺癌小鼠移植瘤的增敏效应[J]. 癌变·畸变·突变, 2010, 22(2): 95-099.
[2]	王　欣, 海春旭, 梁　欣. 刺五加提取物在自由基模型中的活性作用[J]. 癌变·畸变·突变, 2009, 21(2): 127-131.
[3]	张乃哲1 , 张敬一1 ,赵会军1 ,付琳杰1 ,张文智2. 刺五加抗癌作用的实验研究[J]. , 2000, 12(2): 98-101.

刺五加在小鼠实验性肺癌侵袭转移过程中作用

Experimental Study on the Anticancer Role of Acanthopanax Senticosus in the Invasion and Metastasis Process

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