癌变·畸变·突变 ›› 2002, Vol. 14 ›› Issue (1): 41-042.doi: 10.3969/j.issn.1004-616x.2002.01.014

• 短篇报道 • 上一篇    下一篇

大肠癌患者及其家族成员血清免疫抑制酸性蛋白的测定

李明烈;高 丽   

  1. 上海市肿瘤研究所,上海 200032
  • 收稿日期:2000-11-06 修回日期:2000-12-20 出版日期:2002-01-30 发布日期:2002-01-30
  • 通讯作者: 李明烈

DETERMINATION OF SERUM IMMUNOSUPPRESSIVE ACIDIC PROTEIN IN PATIENTS WITH LARGE BOWEL CARCINOMA AND THEIR FAMILIAL MEMBERS

LI Ming-lie ; GAO Li   

  1. Shanghai Cancer Institute , Shanghai 200032 , China
  • Received:2000-11-06 Revised:2000-12-20 Online:2002-01-30 Published:2002-01-30
  • Contact: LI Ming-lie

摘要: 目的:评估大肠癌(LBC) 患者及其家族成员(FM) 血清免疫抑制酸性蛋白( IAP) 水平的变化。方法:应用单向免疫琼脂扩散法检测20 例大肠癌患者和20 例家族成员血清IAP 水平。结果:20 例LBC 患者血清IAP 水平与正常健康人比较有显著差异( P< 0. 01) ,FM组与正常健康人(NS) 比较也有统计学差异( P < 0.01) 。结论: IAP 与大肠癌发生可能相关, IAP 的检测可被用于大肠癌易感个体的筛选。

关键词: 免疫抑制酸性蛋白, 大肠癌, 家族成员

Abstract: Purpose : to evaluate the changes af the serum levels of immunosuppressive acidic protein ( IAP) in patients with large bowel carcinoma (LBC) and their familial members ( FM) . Methods : the serum changes of IAP in the 20 cases with LBC and 20 FM were determined using single immunodiffusion method. Results : the serum levels of IAP in patients with LBC , compared with normal subjects (NS) , were significantly increased ( P < 0. 01) . there also were statistical differences in serum levels between FM and the NS ( P < 0. 01) . conclusion : It is suggested that IAP may probably be associated with carcinogenesis of LBC. The changes of IAP may be served as an indicator of diagnosis for susceptible individuals of LBC.

Key words: immunosuppressive acidic protein, large bowel carcinoma, familial members

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