番茄红素对甲基戊基亚硝胺在大鼠中致癌性的影响

doi:10.3969/j.issn.1004-616x.2001.03.005

癌变·畸变·突变 ›› 2001, Vol. 13 ›› Issue (3): 151-153.doi: 10.3969/j.issn.1004-616x.2001.03.005

番茄红素对甲基戊基亚硝胺在大鼠中致癌性的影响

张庆英1, 黄　革1, 罗家逸1, 沈忠英2, 林　昆1, 沈　健2

11 汕头大学医学院卫生学教研室,广东　汕头　515031 ; 21 汕头大学医学院病理教研室,广东　汕头　515031

收稿日期:2001-01-19 修回日期:2001-04-06 出版日期:2001-07-30 发布日期:2001-07-30

EFFECT OF LYCOPENE ON CARCINOGENICITY OF N-METHYL-N-AMYLNITROSAMINE IN WISTAR RATS

ZHAN G Qing-ying1, HUANG Ge1, LUO Jia-yi1, SHEN Zhong-ying2, etal .

1. Department of Hygiene ; 2. Department of Pathology, Shantou University Medical College, Shantou 515031, China

Received:2001-01-19 Revised:2001-04-06 Online:2001-07-30 Published:2001-07-30

摘要/Abstract

摘要： 目的:观察番茄红素对甲基戊基亚硝胺(MANA) 致癌性的影响。方法:随机将Wistar 大鼠分为3 组:MANA 组(M) 、MANA + 番茄酱组(M + L P) 和对照组(C) 。实验期为26 周,观察大鼠食管和胃粘膜病理变化,同时检测血清活性氧单位(ROS unit) 、超氧化物歧化酶(SOD) 、丙二醛(MDA) 以及全血谷胱甘肽过氧化物酶( GSH2Px) 水平。结果:M 组和M + L P 组大鼠食管和前胃均发生癌前病变,而M + L P 组大鼠癌前病变发生率低于M 组;M + L P 组大鼠血中ROS unit 、SOD、GSH2Px 活性较M组高,MDA 含量较M 组低。结论:番茄红素具有抑制MANA 致癌的作用,其机制可能与抑制脂质过氧化反应有关。

关键词: 亚硝胺:食管癌, 番茄红素, Wistar 大鼠

Abstract: Purpose : To study the effect s of lycopene on the carcinogenicity of N2methyl2N2amylnit rosamine (MANA) in Wistar rat s. Methods : The rat s were randomly divided into three groups : simple MANA (M) ,MANA plus tomato jam (M + L P) and cont rol (C) groups. The experiment lasted 26 weeks. Histological examination was done and the levels of ROS unit , SOD , GSH2Px and MDA in the blood were determined. Results : There were precancerous lesions of esophagus or forestomach in the M and M + L P groups. The incidence of precancerous lesions in the M + L P group was decreased , and the levels of ROS unit , SOD , GSH2Px in the blood were higher , but the content of MDA was decreased. Conclusion : Lycopene may have an inhibitory effect on the carcinogenicity of MANA. The effect may be due to the inhibition of lipid peroxidation.

Key words: nitrosamine, esophageal cancer, lycopene, Wistar rat

中图分类号:

张庆英, 黄　革, 罗家逸, 沈忠英, 林　昆, 沈　健. 番茄红素对甲基戊基亚硝胺在大鼠中致癌性的影响[J]. 癌变·畸变·突变, 2001, 13(3): 151-153.

ZHAN G Qing-ying, HUANG Ge, LUO Jia-yi, SHEN Zhong-ying, etal .. EFFECT OF LYCOPENE ON CARCINOGENICITY OF N-METHYL-N-AMYLNITROSAMINE IN WISTAR RATS[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2001, 13(3): 151-153.

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番茄红素对甲基戊基亚硝胺在大鼠中致癌性的影响

EFFECT OF LYCOPENE ON CARCINOGENICITY OF N-METHYL-N-AMYLNITROSAMINE IN WISTAR RATS

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