关键词: 有机锗, 多酸衍生物, 抗病毒, 细胞病变

Abstract: BACKGROUND ＆ AIM: To study the cytotoxicity on normal cell and antiviral effect of organogermanium Poly-derivatives on breath virus, and provide a basis to clinical application. MATERIAL AND METHODS: The cytoxicity on FL was studied with the method of MTT. Establish the model of breath viral infected in vitro and observe protective function of organogermanium poly-derivatives on infected cells by methods of CPE and MTT. To study the antiviral effect of organogermanium poly-derivatives by changing time, way and concentration of giving medicine. RESULTS： The quantity of surviving cells was more than virus infecting group. When the dosage reached 160.00 μg/ml, inhibiting RSV effect of organogermanium poly-derivatives was higher than the ribavirin group.In the group that the Hela cells were infected by RSV first then treated with organogermanium poly-derivatives,the quantity of alive cell was more than the ribavirin group. CONCLUSION: organogermanium poly-derivatives is a kind of medicine that has definite antiviral function.

Key words: organogermanium, poly-derivatives, antivirus, cytopathic effect