Clusterin在卵巢上皮性癌患者外周血中的蛋白水平及其临床意义

doi:10.3969/j.issn.1004-616x.2011.01.011

›› 2011, Vol. 23 ›› Issue (1): 42-045.doi: 10.3969/j.issn.1004-616x.2011.01.011

Clusterin在卵巢上皮性癌患者外周血中的蛋白水平及其临床意义

吕讷男1,肖汀2,张莹2,姚洪文1,韩迺珺2,程书钧2,吴令英1,高燕宁2*

1. 中国医学科学院北京协和医学院肿瘤医院肿瘤研究所妇瘤科，北京 2. 中国医学科学院北京协和医学院肿瘤医院肿瘤研究所“癌发生及预防分子机理”北京市重点实验室，北京

收稿日期:2010-08-22 修回日期:2010-11-15 出版日期:2011-01-30 发布日期:2011-01-30
通讯作者: 高燕宁

Protein level and clinical significance of clusterin in peripheral blood derived from epithelial ovarian cancer patients

LU Ne-nan1，XIAO Ting2，ZHANG Ying2，YAO Hong-wen1，HAN Nai-jun2，CHENG Shu-jun2，WU Ling-ying1，GAO Yan-ning2，

1. Department of Gynecologic Oncology, Cancer Hospital and Institute, Peking Union Medical College &Chinese Academy of Medical Sciences, Beijing 100021; 2. Beijing Key Laboratory for Carcinogenesis andCancer Prevention, Cancer Hospital and Institute, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing

Received:2010-08-22 Revised:2010-11-15 Online:2011-01-30 Published:2011-01-30
Contact: GAO Yan-ning

摘要/Abstract

摘要： 检测卵巢癌患者外周血中clusterin蛋白水平，并探讨其临床意义。方法：采用酶联免疫吸附分析法分别测定137例卵巢癌患者、12例卵巢交界性肿瘤患者、10例卵巢良性肿瘤患者、41例盆腔良性疾患病人和58例健康人外周血血浆中clusterin蛋白水平。结果：卵巢癌患者血浆中的clusterin蛋白水平[(109.37±52.37) ng/ml]显著高于健康人对照组[(102.61±18.48) ng/ml，P = 0.021]。在卵巢癌患者组，发生远处转移的患者外周血的clusterin蛋白水平显著高于未发生远处转移者(P＜0.01)；血浆中的clusterin蛋白水平在卵巢癌不同分期、分化和有无淋巴转移等临床病理指标间的差异无统计学意义。结论：卵巢癌患者外周血中clusterin蛋白水平显著高于健康人群，并且可能与卵巢癌远处转移有关。

关键词: clusterin, 卵巢上皮性癌, 酶联免疫吸附分析

Abstract: To evaluate clusterin protein level in the peripheral blood samples from epithelial ovarian cancer patients, and to explore its clinical significance. METHODS: Peripheral blood samples were obtained from 137 patients with epithelial ovarian cancer, 12 with borderline ovarian tumor, 10 with benign ovarian tumor, 41 with benign pelvic lesion and 58 healthy women. The plasma clusterin level was measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: The mean level of plasma clusterin in epithelial ovarian cancer patients was significantly higher than that in healthy women (P=0.021). The mean plasma clusterin in epithelial ovarian carcinoma patients with metastasis was significantly higher than those without (P＜0.01). The level of plasma clusterin did not correlate with the stage, grade and lymph node metastasis. CONCLUSION: Plasma clusterin level was increased in the peripheral blood of ovarian cancer patients. In epithelial ovarian carcinoma，the level of plasma clusterin did correlate with distant metastasis.

Key words: clusterin, ovarian cancer, ELISA

吕讷男1,肖汀2,张莹2,姚洪文1,韩迺珺2,程书钧2,吴令英1,高燕宁2*. Clusterin在卵巢上皮性癌患者外周血中的蛋白水平及其临床意义[J]. , 2011, 23(1): 42-045.

LU Ne-nan1，XIAO Ting2，ZHANG Ying2，YAO Hong-wen1，HAN Nai-jun2，CHENG Shu-jun2，WU Ling-ying1，GAO Yan-ning2，. Protein level and clinical significance of clusterin in peripheral blood derived from epithelial ovarian cancer patients[J]. , 2011, 23(1): 42-045.

[1]	李　敏1/ 张　蕾2/ 肖　汀1/ 张　莹1/韩　　 1/程书钧1/ 王贵齐2/ 高燕宁1,. 肺泡灌洗液中多聚免疫球蛋白受体分泌片段测定的临床意义[J]. , 2008, 20(5): 398-401.
[2]	欧玉荣;张洪福;刘德纯. 结直肠癌患者血清及粪便中P53基因检测的临床意义[J]. , 2005, 17(6): 370-373.

Clusterin在卵巢上皮性癌患者外周血中的蛋白水平及其临床意义

Protein level and clinical significance of clusterin in peripheral blood derived from epithelial ovarian cancer patients

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