中药蛇床子水溶性提取物中化学成分的抗诱变性研究

doi:10.3969/j.issn.1004-616x.1999.02.002

Carcinogenesis, Teratogenesis & Mutagenesis ›› 1999, Vol. 11 ›› Issue (2): 65-071.doi: 10.3969/j.issn.1004-616x.1999.02.002

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A STUDY ON THE ANTIMUTAGENICITY OF CHEMICAL COMPOUNDS EXTRACTED FROM CNIDIUM MONNI ERI ( L) CUSS USED IN CHINESE TRADITIONAL MEDICINE

Yin Xuejun1 , Xiang Rende2 , Liu Dexiang1 , Zhang Xinyong2 , Xu Yonghua1 , Han Ying2 , Wang Rui1 , Wang Hechuan1

1 Instit ute of Clinical Medicine , Urumqi General Hospital of L anz hou Com mand , PL A , Urumqi 　830000 , 2Nanjing Instit ute of Materia Medica , Nanjing 　210009

Received:1998-07-20 Revised:1998-10-28 Online:1999-03-30 Published:1999-03-30

Abstract

Abstract: The antimutagenicity of 9 kinds of chemical compounds (osthol , Bergaten , Isopimpinellin , Imperatorin , Xanthotoxol , Xnthotoxin , Thymine , Uracil and unknown one that need authenticating) was studied with the Ames test and the micronucleus and chromosomal aberretion assays in mice in vivo. These compounds were isolated f rom the water ext ract of Cnidium monnieri (L. ) Cuss in Chinese t raditional medicine. The results showed that osthol. , bergapten , isopimpinellin , imperatorin , xanthotoxol and xanthotoxin had inhibited activity of mutagenicity of aflatoxin B1 . And osthol , bergapten , isopimpinellin , imperatorin also had high activity in inhibiting the chromosomal aberrations and micronuclei that induced by cyclophosphamid in vivo. The other three compounds ( Thymine , Uracil and unknown one that need authenticating) showed no antimutagenicity.

Key words: Cnidium monnieri (L. ) Cuss, chemical compound, antimutagenicity

Yin Xuejun , Xiang Rende , Liu Dexiang , Zhang Xinyong , Xu Yonghua , Han Ying , Wang Rui , Wang Hechuan. A STUDY ON THE ANTIMUTAGENICITY OF CHEMICAL COMPOUNDS EXTRACTED FROM CNIDIUM MONNI ERI ( L) CUSS USED IN CHINESE TRADITIONAL MEDICINE[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 1999, 11(2): 65-071.

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A STUDY ON THE ANTIMUTAGENICITY OF CHEMICAL COMPOUNDS EXTRACTED FROM CNIDIUM MONNI ERI ( L) CUSS USED IN CHINESE TRADITIONAL MEDICINE

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