Abstract: Purpose : To research the teratogenic effect of recombinant staphylokinase ( r - SAK) on ICR mice. Methods : The animals were divided into negative and positive cont rol and three experiment groups which were int ravenously given by r - SAKf rom Day 6 to Day 15 of gestation in dosages of 100mg/ kg. bw , 31. 6mg/ kg. bw and 10mg/ kg. bw , respectively. The body growth gains of gestation mice , the numbers , body weight , length and tail length in living fetus and some indicators of embryonic formation were measured. Results : There were no significant differences as compared with negative cont rol groups. Besides , the deformity of the appearances , internal organs and bone in fetal mice was not found. Conclusion : The result s indicated that r - SAK had no teratogenic effect on ICR mice in this experiment .

Key words: recombinant staphylokinase, teratogenicity