蛋白质组学研究技术及其在烷化剂引起的细胞应答反应研究中的应用

doi:10.3969/j.issn.1004-616x.2002.03.017

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2002, Vol. 14 ›› Issue (3): 195-199.doi: 10.3969/j.issn.1004-616x.2002.03.017

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PROGRESS IN PROTEOMICS TECHNOLOGIES AND THE APPLICATION IN STUDYING CELLULAR RESPONSES TO AN ALKYLATING AGENT

JIN Jing-hua ,YU Ying-nian

Department of Pathophysiology, School of Medicine Zhejiang University, Hangzhou 　310031, China

Received:2002-03-26 Revised:2002-04-09 Online:2002-07-30 Published:2002-07-30
Contact: YU Ying-nian

Abstract

Abstract: Proteomics is a newly emerging field in the post2genomics era. The development of knowledge and technologies in proteomics has provided a new way to understand the molecular mechanisms of mutagenesis induced by carcinogens. This review described the principal progress in proteomics technologies including two2dimensional gel elect rophoresis , mass spect romert ry and bioinformatics , and showed the preliminary result s in application to studying cellular responses to low concent ration of alkylating agent in our lab.

Key words: proteomics, alkylating agent, response

CLC Number:

R329

JIN Jing-hua , YU Ying-nian. PROGRESS IN PROTEOMICS TECHNOLOGIES AND THE APPLICATION IN STUDYING CELLULAR RESPONSES TO AN ALKYLATING AGENT[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2002, 14(3): 195-199.

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PROGRESS IN PROTEOMICS TECHNOLOGIES AND THE APPLICATION IN STUDYING CELLULAR RESPONSES TO AN ALKYLATING AGENT

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