体外培育牛黄的诱变性研究

doi:10.3969/j.issn.1004-616x.2003.01.010

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2003, Vol. 15 ›› Issue (1): 35-37.doi: 10.3969/j.issn.1004-616x.2003.01.010

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STUDY ON MUTAGENICITY OF CULTURED CALCULUS BOVIS

XU Yi-ping, SONG Rui-kun, SHI Nian, et al.

Department of Health Toxicology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030 , China

Received:2002-07-10 Revised:2002-08-23 Online:2003-01-30 Published:2003-01-30
Contact: SHI Nian

Abstract

Abstract: Purpose: To study the mutagenicity of Cultured Calculus Bovis. Methods: The studies were conducted with Ames test, micronuclei test and in vitro chromosome aberration test on human lymphocyte. Results: ① The results of Ames test showed no mutagenic effects with the concentration ranged from 1 250 μg / plate to 10 000 μg / plate. ② In micronuclei test, the mice orally received 50, 150, 500 mg / kg respectively per day for 2 days, no mutagenic effects were observed; and no significant reduction was observed on PCE / NCE ratio, compared with that of the negative control group(P>0.05). ③ The in vitro chromosome aberration test on human lymphocyte showed a negative result with the sample concentration ranged from 1 μg / ml to 100 μg / ml. Conclusion: No mutagenicity was found with Cultured Calculus Bovis in this experimentation.

Key words: Cultured Calculus Bovis, Mutagenicity, Chromosome aberration

XU Yi-ping, SONG Rui-kun, SHI Nian, et al.. STUDY ON MUTAGENICITY OF CULTURED CALCULUS BOVIS[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2003, 15(1): 35-37.

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STUDY ON MUTAGENICITY OF CULTURED CALCULUS BOVIS

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