Carcinogenesis, Teratogenesis & Mutagenesis ›› 2004, Vol. 16 ›› Issue (1): 46-49.doi: 10.3969/j.issn.1004-616x.2004.01.014

Previous Articles     Next Articles

Inhibitory Effect of AMH Extracted from Fungi Plant Tricholoma Matsutake on the Mutagenicity of Cigarette Smoke Condensate in vitro

HE Xiao-qiong;CHEN Yan-hong;XIONG Xiang-ling   

  1. Nutrition and Food Science Institute, Kunming Medical College, Kunming 650031, China
  • Received:2003-06-30 Revised:2003-07-30 Online:2004-01-30 Published:2004-01-30
  • Contact: HE Xiao-qiong

PDF (PC)

2922

Abstract: BACKGROUND ＆ AIM: To find safe and effective bio-antimutagenic resources for the prevention of tumor and the reduction of the genetic damage of CSC (Cigarette Smoke Condensate).MATERIAL AND METHODS: The antimutagenic effect of AMH (Antimutagenic Herb) on CSC was studied by the revised Ames test.RESULTS: Ames test showed CSC was a shamshelft mutagen,and AMH could significantly inhibit the mutagenicity of CSC(P< 0.01). The highest inhibitory rates of the revertant colonies induced by CSC in strains TA97 and TA98 were 97.0 ％ and 96.1 ％,respectively. The revertant colonies induced by CSC reduced to the negative ranges when AMH was added. And the significant dose-effect relationship existed in the antimutagenicity.CONCLUSION: AMH could significantly inhibit the mutagenicity of CSC. AMH was an effective antimutagen, and it might be useful in cancer prevention and the reduction of genetic damage of CSC.

Key words: mutagenicity, antimutagenicity, tumor prevention, fungi plant, Tricholoma matsutake, cigarette smoke condensate