Carcinogenesis, Teratogenesis & Mutagenesis ›› 2004, Vol. 16 ›› Issue (6): 349-351.doi: 10.3969/j.issn.1004-616x.2004.06.010

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Study on Vitro Anti-respiratory Virus Infection Effect of Organogermanium Poly-derivatives

TIAN Li-li， ZHANG Gui-ying， WANG Bao-gui， et al   

  1. College of Preventive Medicine,Jilin University,Changchun 130021, China
  • Received:2004-04-08 Revised:2004-04-16 Online:2004-11-30 Published:2004-11-30
  • Contact: TIAN Li-li

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Abstract: BACKGROUND ＆ AIM: To study the cytotoxicity on normal cell and antiviral effect of organogermanium Poly-derivatives on breath virus, and provide a basis to clinical application. MATERIAL AND METHODS: The cytoxicity on FL was studied with the method of MTT. Establish the model of breath viral infected in vitro and observe protective function of organogermanium poly-derivatives on infected cells by methods of CPE and MTT. To study the antiviral effect of organogermanium poly-derivatives by changing time, way and concentration of giving medicine. RESULTS： The quantity of surviving cells was more than virus infecting group. When the dosage reached 160.00 μg/ml, inhibiting RSV effect of organogermanium poly-derivatives was higher than the ribavirin group.In the group that the Hela cells were infected by RSV first then treated with organogermanium poly-derivatives,the quantity of alive cell was more than the ribavirin group. CONCLUSION: organogermanium poly-derivatives is a kind of medicine that has definite antiviral function.

Key words: organogermanium, poly-derivatives, antivirus, cytopathic effect