Abstract: BACKROUND＆AIM: To discuss the protective effects of ammonia against phosgene on mice , in order to find a new therapy for lung injury induced by phosgene. MATERIAL AND METHODS: During phosgene exposure, the treated groups were protected by different dose of ammonia. After 3 h, all mice were anatomized to measure malondialdehyde(MDA),reduced glutathione(GSH),oxidized glutathione(GSSG)of lung and glutathione peroxidase(GSH_Px)of blood by fluorescence_metry. RESULTS: MDA,GSH,GSSG were different significantly between control and positive group. With compared with positive group, MDA and GSSG of trial group was lower(P<0.05). CONCLUSION: There were some oxidative injury occurred in lung during phosgene exposure and ammonia may have protective effect on it.

Key words: phosgene, ammonia, oxidative injury