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doi:10.3969/j.issn.1004-616x.2006.01.008

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2006, Vol. 18 ›› Issue (1): 26-028.doi: 10.3969/j.issn.1004-616x.2006.01.008

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Teratogenicity of Arbidol Hydrochloride in Rats

ZHOU Yi-ping;CHEN Qi-you;CHEN Si-yan;YANG Jing-hua

Hubei Pharmaceutical Industry Research Institute,Wuhan 430061,China

Received:2005-01-17 Revised:2005-06-28 Online:2006-01-30 Published:2006-01-30
Contact: ZHOU Yi-ping

Abstract

Abstract: BACKGROUND ＆ AIM: To observe the teratogenicity of Arbidol hydrochloride(Ar) orally administered to rats. MATERIAL AND METHODS： Doses of Ar 100、330 and 1 000 mg/(kg·d) were given orally to the 6－15 d pregnant rats. The rats were sacrificed on day 20. RESULTS: The reduced parental body weight and number of live fetuses, as well as reduced pup weight and length, delayed ossification were observed in the rats treated with the daily dose of 1 000 mg/(kg·d). Compared with vehicle control group, no external, visceral and skeletal malformations were seen in these infant rats. No adverse effects were observed in the rats treated with the daily doses of 100 and 330 mg/kg. CONCLUSION: Ar 330 mg/kg was a safe dose in pregnant rats and 1 000 mg/kg had embryotoxic but without teratogenic effects in rats.

Key words: Arbidol hydrochloride, rat, teratogenicity, embryo toxicity, toxicology

CLC Number:

ZHOU Yi-ping, CHEN Qi-you, CHEN Si-yan, YANG Jing-hua. Teratogenicity of Arbidol Hydrochloride in Rats[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2006, 18(1): 26-028.

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Teratogenicity of Arbidol Hydrochloride in Rats

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