溴氰菊酯对大鼠脑组织线粒体膜电位和膜流动性的影响

doi:10.3969/j.issn.1004-616x.2006.04.001

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2006, Vol. 18 ›› Issue (4): 257-260.doi: 10.3969/j.issn.1004-616x.2006.04.001

Effects of Deltamethrin on Mitochondrial Membrane Potential and Membrane Fluidity in Rats Brain Tissue

CHEN Dan, SHI Nian, LI Huang-yuan, LIU Lin-lin

Department of Health Toxicology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, Hubei，China

Received:2005-09-12 Revised:2005-12-19 Online:2006-07-30 Published:2006-07-30
Contact: Shi Nian

Abstract

Abstract: BACKGROUND ＆ AIM: To study the effects of deltamethrin(DM) on mitochondrial membrane potential and membrane fluidity in rat brain tissue. MATERIAL AND METHODS: Male adult Wistar rats were treated intraperitonealy with 12.5 mg/kg DM. At 5, 24, 48 and 72 h after injection, we extracted the mitochondria of rat brain tissue to measure the membrane potential, membrane fluidity, activities of Na＋-K＋-ATPase、Ca2＋-Mg2＋-ATPase and succinic dehydrogenase.At the same time the control group were merely injected intraperitonealy with 0.5 mg/100 g salad oil and then executed after 5 h. RESULTS: After treatment with deltamethrin, the mitochondrial membrane potential decreased, membrane fluidity was reduced, the activities of Na＋-K＋-ATPase,Ca2＋-Mg2＋-ATPase and succinic dehydrogenase were inhibited (P<0.01). Moreover, there were correlations between those indexes and time after treatment. CONCLUSION: DM had obvious effects on inhibiting the mitochondrial function of rat brain tissue, then caused the impairment of oxidative phosphorylation in the mitochondria.

Key words: deltamethrin, mitochondria, membrane potential, membrane fluidity

CLC Number:

R 994

CHEN Dan, SHI Nian, LI Huang-yuan, LIU Lin-lin. Effects of Deltamethrin on Mitochondrial Membrane Potential and Membrane Fluidity in Rats Brain Tissue[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2006, 18(4): 257-260.

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Effects of Deltamethrin on Mitochondrial Membrane Potential and Membrane Fluidity in Rats Brain Tissue

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