食管早期鳞癌的神经内分泌分化及其意义

doi:10.3969/j.issn.1004-616x.2006.06.012

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2006, Vol. 18 ›› Issue (6): 459-461.doi: 10.3969/j.issn.1004-616x.2006.06.012

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Neuroendocrine Differentiation and Its Significance in Early Esophageal Squamous Cell Carcinoma

DU Yun,WANG Yong-jun,YANG Hui-chai,WANG Xiao-ling,WU Guo-xiang, ZUO Lian-fu

(Pathology Department of Hebei Tumour Hospital，Shijiazhuang 050011，China)

Received:2005-11-02 Revised:2005-12-23 Online:2006-11-30 Published:2006-11-30
Contact: DU Yun

Abstract

Abstract: 【ABSTRACT】 BACKGROUND ＆AIM： Study prognostic significance of neuroendine(NE) differentiation in early esophageal squamous cell carcinoma(ESCC). MATERIALS AND METHODS： Expressions of CgA，Syn and PCNA in 48 cases of ESCC were detected by immunohistochemistry， and their prognostic significances in early ESCC were studied. RESULTS： Positive rates of CgA and Syn were 33.3％ and 22.9％, respectively. Expression of CgA was not correlated with the depth of invasion and differentiation(P=0.601, 0.091). Expression of Syn was not correlated with the depth of invasion (P=0.663), but correlated with differentiation(P=0.033).CgA and Syn were correlated with PCNA(rs=0.299, P=0.039; rs=0.288, P=0.047).Cox regression revealed that only tumor differentiation and the depth of invasion were independent prognostic factors. CONCLUSION： There was no correlation between NE differentiation and prognosis of ESCC.

Key words: esophageal cancer, neuroendocrine differentiation, CgA, Syn

CLC Number:

R730.7

DU Yun, WANG Yong-jun, YANG Hui-chai, WANG Xiao-ling, WU Guo-xiang, ZUO Lian-fu. Neuroendocrine Differentiation and Its Significance in Early Esophageal Squamous Cell Carcinoma[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2006, 18(6): 459-461.

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Neuroendocrine Differentiation and Its Significance in Early Esophageal Squamous Cell Carcinoma

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