Carcinogenesis, Teratogenesis & Mutagenesis ›› 2007, Vol. 19 ›› Issue (1): 73-075.doi: 10.3969/j.issn.1004-616x.2007.01.022

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Analysis of p16 Gene Deletion and Mutation in Breast Cancer

LI Tie-chen1，LIU Ping2，SUN Hui-lan1，XU Yu-qi1   

  1. 1.Laboratory of Medical Genetics，2.Department of Oncology, the Affiliated Yijishan Hospital, Wannan Medical College, Wuhu 241001,China
  • Received:2006-05-12 Revised:2006-10-25 Online:2007-01-30 Published:2007-01-30

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Abstract: BACKGROUND ＆ AIM: To investigate p16 gene alterations in breast cancer. MATERIALS AND METHODS: 33 fresh tumor specimens taken from breast cancer patients were analyzed for p16 gene deletion and mutation by polymerase chain reaction (PCR) and DNA sequencing. RESULTS: No homozygous deletion of p16 gene exon 1, 2 and 3 was observed in any of the 33 cases and no point mutation of p16 gene exon 2 was detected in 10 specimens. CONCLUSION: The finding suggested that there was little or no relationship between the homozygous deletion and point mutation of p16 gene and breast carcinogenesis.

Key words: breast neoplasms;p16 gene, homozygous deletion;point mutation

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