子宫内膜癌p21WAF1/CIP1蛋白的表达及其意义

doi:10.3969/j.issn.1004-616x.2007.04.021

Abstract

Abstract: BACKGROUND＆AIM： To investigate the expression of p21WAF1/CIP1 protein in endometrial carcinoma and its clinical significance. MATERIALS AND METHODS： p21WAF1/CIP1 protein was assessed in 30 normal controls, 20 single hyperplasia, 22 atypical hyperplasia, 57 endometrial carcinoma by immunohistochemical SP method. RESULTS：p21WAF1/CIP1 protein was mainly expressed in the nucleolus . Its expression protein was decreased in endometrial carcinoma tissue，compared with normal controls and single hyperplasia(P<0.01). The expression of p21WAF1/CIP1 was correlated with depth of myometrial invasion and clinical stage (P<0.05). CONCLUSION： p21WAF1/CIP1 protein may play an important role in the development and prognosis of endometrial carcinoma.

Key words: immunohistochemistry, p21WAF1/CIP1 protein, endometrial carcinoma

GE Xiu_jun, LIU Zhi_hui, GAO Rui_ping. Expression and Significance of p21WAF1/CIP1 in Protein Endometrial Carcinoma[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2007, 19(4): 338-340.

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Expression and Significance of p21WAF1/CIP1 in Protein Endometrial Carcinoma

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