Carcinogenesis, Teratogenesis & Mutagenesis ›› 2007, Vol. 19 ›› Issue (5): 366-369.doi: 10.3969/j.issn.1004-616x.2007.05.006

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Expressions of PTEN，NF_κBp65 and CyclinD1 in Gastric Adeno_carcinoma and Their Correlations with Clinicopathologic of the Tumor

LI Peng1，YANG Gui_fang2,CHEN Jian_ou1,HUANG Ka_te1,ZHAO Jing1   

  1. (1. Department of Pathology, The Frist Affiliated Hospital of Wenzhou Medical College, Wenzhou, 325000; 2. Department of Pathology, Zhongnan Hospital, Wuhan University,Wuhan 430071,China)
  • Received:2006-12-15 Revised:2007-03-09 Online:2007-09-30 Published:2007-09-30
  • Contact: LI Peng

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Abstract: BACKGROUND ＆ AIM: To investigate the protein expressions of PTEN, NF_κBp65 and CyclinD1 in gastric adenocarcinoma and the relationship between their expressions and clinicolpathological features. MATERIALS AND METHODS: Protein expressions of PTEN, NF_κBp6 and CyclinD1 in paraffin embedded tissues from 73 cases of gastric adenocarcinoma and 20 normal gastric mucosa tissues were analyzed by immunohistochemical method. RESULTS: ①The positive rate of PTEN protein expression was 42.5％(31/73)in gastric adenocarcinoma, lower than that in normal gastric mucosa tissues 90％(18/20)(P<0.01); The positive rates of NF_κBp65 and CyclinD1 protein expression were 58.9％(43/73)and 60.3％(44/73),respectively in gastric adenocarcinoma, higher than those in normal gastric mucosa tissues 20％(4/20)and 25％(5/20),respectively(both P<0.01); ②The expression of PTEN in well_differentiated adenocarcinoma was higher than that in poorly_differentiated adenocarcinoma (P<0.01). Also, the loss or decreased expression of PTEN significantly correlated with infiltrative depth, lymph node metastasis and clinicolpathological stage (P<0.01 or P<0.05). Contrary to PTEN, the expression level of NF_κBp65 in poorly_differentiated adenocarcinoma was higher than that in well_differentiated ones(P<0.05), and the increased expression of NF_κBp65 significantly correlated with infiltrative depth, lymph node metastasis and clinicolpathological stage(P<0.05 or P<0.01).The expression level of CyclinD1 only correlated with infiltrative depth of gastric adenocarcinoma(P<0.05); ③Significant relationships were found between PTEN and NF_κBp65 or CyclinD1(P<0.05, P<0.01), while a positive correlation could also be found between NF_κBp65 and CyclinD1(P<0.05). CONCLUSION: This expreiment suggested that PTEN, NF_κBp65 and CyclinD1 may play certain roles in the oncogenesis and progression of gastric adenocarcinoma, but to different extents. Combined evaluation of PTEN, NF_κBp65 and CyclinD1 may be helpful to assess the malignant degree,treatment and prognosis of gastric adenocarcinoma.

Key words: gastric adenocarcinoma, PTEN, NF_κBp65, cyclinD1, immunohistochemistry

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