Carcinogenesis, Teratogenesis & Mutagenesis ›› 2008, Vol. 20 ›› Issue (1): 11-014.doi: 10.3969/j.issn.1004-616x.2008.01.003

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Association between Genetic Polymorphisms of CYP1A1 and Lung Cancer Susceptibility for People Living in High Radon-exposed Area

QI Xue-song1, XIA Ying1, SUN Quan-fu1, SHANG Bing1,LU Hui-ming1, CHENG Tong-xin2, CUI Hong-xing1, FENG Shun-zhi2,WANG Li-ping1, WANG Hao3, SUN Fen-zhen3   

  1. National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing
  • Received:2007-11-13 Revised:2007-11-20 Online:2008-01-30 Published:2008-01-30

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Abstract: BACKGROUND AND AIM: To assess the role of genetic polymorphisms of metabolic enzyme Cytochrome P450 1A1(CYP1A1) in the risk of developing lung cancer for the people living in high radon-exposed area. MATERIALS AND METHODS: A case-control study was performed with 53 lung cancer patients and 72 frequency-matched controls. The associations between genotypes and risk of developing lung cancer were estimated by odds ratios (ORs) and their 95％ confidence intervals (CIs) calculated by unconditional logistic regression. RESULTS: Risk of developing lung cancer for heterozygous CYP1A1 (MSPⅠ) polymorphism was 1.03-fold (95％CI 0.468－2.28) higher than that for wild type of CYP1A1 (MSPⅠ) polymorphism. Stratified analysis showed that with effective dose<50 mSv the risk of developing lung cancer for heterozygous CYP1A1 (MSPⅠ) polymorphism increased to 4.29-fold (95％CI 0.582－88.2). In people heterozygous for CYP1A1 (MSPⅠ) polymorphism aged between 40 and 59, the risk of developing lung cancer was 1.22-fold higher than that for wild type of CYP1A1 (MSPⅠ) polymorphism. CONCLUSION: The present results indicated genetic polymorphisms of CYP1A1 might increase the risk of developing lung cancer, but the difference was not statistically significant.

Key words: radon, CYP1A1, genetic polymorphisms, lung cancer susceptibility